Therapeutic effect of α-galactosylceramide-loaded dendritic cells genetically engineered to express SLC/CCL21 along with tumor antigen against peritoneally disseminated tumor cells

MATSUYOSHI Hidetake; HIRATA Shinya; YOSHITAKE Yoshihiro; MOTOMURA Yutaka; FUKUMA Daiki; KURISAKI Akari; NAKATSURA Tetsuya; NISHIMURA Yasuharu; SENJU Satoru

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J-GLOBAL ID：200902243106779173 Reference number：06A0033098

Therapeutic effect of α-galactosylceramide-loaded dendritic cells genetically engineered to express SLC/CCL21 along with tumor antigen against peritoneally disseminated tumor cells

腫よう抗原と共にSLC/CCL21を発現するよう遺伝子組み換えしたα-ガラクトシルセラミド負荷樹状細胞の腹腔播種腫よう細胞に対する治療効果

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Material：
Volume： 96 Issue： 12 Page： 889-896 Publication year： Dec. 2005
JST Material Number： W1423A ISSN： 1347-9032 Document type： Article
Article type：原著論文 Country of issue： Australia (AUS) Language： ENGLISH (EN)

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Experimental treatment for tumors , Tumor immunity , Gene manipulation

Reference (38)：

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TOURA, I. Cutting edge : inhibition of experimental tumor metastasis by dendritic cells pulsed with α-galactosylceramide. J Immunol. 1999, 163, 2387-2391
FUJII, S. Prolonged IFN-γ-producing NKT response induced with alpha-galactosylceramide-loaded DCs. Nat Immunol. 2002, 3, 867-874
BEZBRADICA, JS. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J Immunol. 2005, 174, 4696-4705
GONZALEZ-ASEGUINOLAZA, G. α-Galactosylceramide-activated Vα 14 natural killer T cells mediate protection against murine malaria. Proc Natl Acad Sci USA. 2000, 97, 8461-8466

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