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J-GLOBAL ID：200902243839936097   Reference number：03A0488674

Purification and Properties of a Carbonyl Reductase Involved in Stereoselective Reduction of Ethyl 4-Chloro-3-oxobutanoate from Cylindrocarpon sclerotigenum IFO 31855

Cylindrocarpon sclerotigenum IFO31855由来のエチル4-クロロ-3-オキソブタノアートの立体選択性還元に関与するカルボニルレダクターゼの精製および性質

Author (5)： SARATANI Y (Osaka Prefecture Univ., Osaka, JPN) ,  UHEDA E (Osaka Prefecture Univ., Osaka, JPN) ,  YAMAMOTO H (Daicel Chemical Ind. Ltd., Ibaraki, JPN) ,  NISHIMURA A (Osaka Prefecture Univ., Osaka, JPN) ,  YOSHIZAKO F (Osaka Prefecture Univ., Osaka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 67  Issue： 6  Page： 1417-1420  Publication year： Jun. 23, 2003 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Hyphomycetes ,...
Semi thesaurus term： oxidoreductase ,...

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JST classification (1)： Enzyme in general  (EB09010D)

Substance index (23)： Diacetyl ,  Cyclohexanone ,  1-Hydroxy-2-propanone ,  2,3-Pentanedione ,  Acetylacetone ,  2-Nitrobenzaldehyde ,  3-Nitrobenzaldehyde ,  4-Nitrobenzaldehyde ,  2-Chlorobenzaldehyde ,  3-Chlorobenzaldehyde ,  4-Chlorobenzaldehyde ,  DL-Glyceraldehyde ,  Xylose ,  Galactose ,  Glucose ,  Dicoumarol ,  4-Chloroacetoacetic acid ethyl ,  Acetoacetic acid ethyl ,  Methyl 3-oxopentanoate ,  Ethyl 2-methyl-3-oxobutanoate ,  Pyruvic acid ethyl ,  Pyridine-3-carbaldehyde ,  5,5′-Thiobis(2-nitrobenzoic acid)

Reference (23)：

• 1) Zhou, B., Gopalan, A. S., Van Middlesworth, F., Shieh, W.-R., and Sih, C. J., Stereochemical control of yeast reductions. 1. Asymmmetric synthesis of L-carnitine. J. Am. Chem. Soc., 105, 5925-5926 (1983).
• 2) Karanewsky, D. S., Badia, M. C., Ciosek, C. P. Jr., Robl, J. F., Sofia, M. J., Simkins, L. M., DeLang, B., Harrity, T. W., Biller, S. A., and Gordon, E. M., Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[2-(Arylethyl)hydroxyphosphinyl]-3-hydroxybutanoic acids: A new class of cell-selective inhibitors of cholesterol biosynthesis. J. Med. Chem., 33, 2952-2956 (1990).
• 3) Shimizu, S., Kataoka, M., Morishita, A., Katoh, M., Morikawa, T., Miyoshi, T., and Yamada, H., Microbial asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to optically active ethyl 4-chloro-3-hydroxybutanoate. Biotechnol. Lett., 12, 593-596 (1990).
• 4) Hunt, J. R., Carter, A. S., Murrell, J. C., Dalton, H., Hallinan, K. O., Grout, D. H. G., Holt, R. A., and Crosby, J., Yeast catalysed reduction of β-keto esters (1): Factors affecting whole-cell catalytic activity and stereoselectivity. Biocatal. Biotransform., 12, 159-178 (1995).
• 5) Yasohara, Y., Kizaki, N., Hasegawa, J., Takahashi, S., Wada, M., Kataoka, M., and Shimizu, S., Synthesis of optically active ethyl 4-chloro-3-hydroxybutanoate by microbial reduction. Appl. Microbiol. Biotechnol., 51, 847-851 (1999).

Terms in the title (6)： Cylindrocarpon ,  立体選択性 ,  還元 ,  カルボニルレダクターゼ ,  精製 ,  性質