Art

J-GLOBAL ID：200902244033083554   Reference number：09A0972222

Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformation

蛋白質局所立体配座に及ぼすヒトカテプシンAの発現及びArg344アミノ酸置換効果の分子動力学研究

Author (10)： YOSHIDA Tatsusada (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  KADOTA Yoshito (Dep. of Public Health, Fac. of Pharmaceutical Sciences, Tokushima Bunri Univ., 180 Yamashiro-cho, Tokushima 770-8514 ...) ,  HITAOKA Seiji (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  KORI Eri (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  HORIKAWA Yasushi (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  TAGUCHI Masahiro (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  TSUJI Daisuke (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  HIROKAWA Takatsugu (Computational Biology Res. Center (CBRC), National Inst. of Advanced Industrial Sci. and Technol. (AIST), 2-43 17F ...) ,  CHUMAN Hiroshi (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN) ,  ITOH Kohji (Inst. of Health Biosciences, The Univ. of Tokushima Graduate School, 1-78 Shomachi, Tokushima 770-8505, JPN)
Material： Biochimica et Biophysica Acta  (BBA. Biomembranes)
Volume： 1794  Issue： 11  Page： 1693-1699  Publication year： Nov. 2009 
JST Material Number： B0207A  ISSN： 0005-2728  CODEN： BBBMBS  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： human ,  *carboxypeptidase ,  *gene expression ,  steric conformation ,  *base pair substitution ,  Computer Simulation ,  lysosome ,  neuraminidase ,  beta-Galactosidase ,  chymotrypsin inhibitor ,  mutant ,  site-directed mutagenesis ,  zymogen ,  metabolic disease ,  fibroblast ,  cultured cell ,  proteolysis ,  *Amino Acid Substitution ,  *Cathepsin A ,  neuraminidase 1 ,  Molecular Dynamics Simulation ,  *molecular genetic phenomenon ,  computer application ,  utilization
Semi thesaurus term： galactosialidosis ,  chymostatin ,  Serine Carboxypeptidase I ,  zymogen

JST classification (2)： Gene expression  (EC02040Q) ,  Enzyme in general  (EB09010D)

Terms in the title (9)： 蛋白質 ,  立体配座 ,  ヒト ,  カテプシンA ,  発現 ,  アミノ酸 ,  置換効果 ,  分子動力学 ,  研究