Art

J-GLOBAL ID：200902244933306281   Reference number：06A0403929

Effect of -361 G/A Polymorphism of Aldehyde Dehydrogenase-2 Gene on Alcohol Metabolism and Its Expression in Human Peripheral Blood Leukocytes

アルデヒドデヒドロゲナーゼ-2遺伝子の-361G/Aの多形がアルコール代謝およびヒト末梢血白血球中の発現に及ぼす影響

Author (5)： NISHIMURA Fusae T. (Kanazawa Univ. School of Medicine, Kanazawa) ,  KIMURA Yukiko (Kanazawa Univ. School of Medicine, Kanazawa) ,  ABE Shuntaro (Jikei Univ. School of Medicine, Tokyo) ,  FUKUNAGA Tatsushige (Tokyo Metropolitan Government, Tokyo) ,  SAIJOH Kiyofumi (Kanazawa Univ. School of Medicine, Kanazawa)
Material： 日本アルコール・薬物医学会雑誌  (Japanese Journal of Alcohol Studies & Drug Dependence)
Volume： 41  Issue： 2  Page： 108-119  Publication year： Apr. 28, 2006 
JST Material Number： G0193B  ISSN： 1341-8963  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *aldehyde dehydrogenase ,...
Semi thesaurus term： personal equation ,...

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JST classification (2)： Poisoning in general  (GD06010Q) ,  Molecular genetics in general  (EC02010J)

Substance index (1)： Acetaldehyde

Reference (29)：

• IKAWA, M. Isolation and characterization of aldehyde dehydrogenase isozymes from usual and atypical human livers. J. Biol. Chem. 1983, 258, 10, 6282-6287
• HSU, L. C. Cloning of cDNAs for human aldehyde dehydrogenase 1 and 2. Proc. Natl. Acad. Sci. USA. 1985, 82, 3771-3775
• SHIBUYA, A. Frequency of the atypical aldehyde dehydrogenase-2 gene (ALDH2^2_2) in Japanese and Caucasians. Am. J. Hum. Genet. 1988, 43, 741-743
• HARADA, S. Genetic polymorphism of alcohol metabolizing enzymes and its implication to human ecology. J. Anthrop. Soc. Nippon. 1991, 99, 2, 123-139
• SUZUKI, K. A study on ADH2 and ALDH2 genotyping by PCR-RFLP and SSCP analysis with description of allele and genotype frequencies in Japanese, Finn, and Lapp populations. Alcohol Alcohol. 1994, 29, Suppl. 1, 21-27

Terms in the title (7)： アルデヒドデヒドロゲナーゼ ,  遺伝子 ,  多形 ,  アルコール代謝 ,  ヒト ,  末梢血白血球 ,  発現