Art

J-GLOBAL ID：200902245120315530   Reference number：09A0697854

Nucleophilic substitution approach to 4′-substituted thymidines by employing 4′-benzenesulfonyl leaving group

4′-ベンゼンスルホニル脱離基を使用する求核置換によって4′-置換-チミジン類を合成する方法

Author (5)： SHIMADA Hisashi (School of Pharmaceutical Sciences, Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JPN) ,  KIKUCHI Satoshi (School of Pharmaceutical Sciences, Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JPN) ,  OKUDA Saori (School of Pharmaceutical Sciences, Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JPN) ,  HARAGUCHI Kazuhiro (School of Pharmaceutical Sciences, Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JPN) ,  TANAKA Hiromichi (School of Pharmaceutical Sciences, Showa Univ., 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, JPN)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 65  Issue： 31  Page： 6008-6016  Publication year： Aug. 01, 2009 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *nucleoside analog ,  asymmetric synthesis ,  *nucleophilic substitution reaction ,  *organosilicon compound ,  tin chloride ,  sulfone ,  regiospecific reaction

JST classification (1)： Nucleosides,nucleotides  (CF10060K)

Substance index (13)： Allyltrimethylsilane ,  Trimethylaluminum ,  Trimethylsilyl azide ,  3′-O-(tert-Butyldimethylsilyl)-5′-deoxy-5′-oxothymidine ,  1-[(2R)-4α-(tert-Butyldimethylsilyl)-5β-(phenylthio)-5-(hydroxymethyl)tetrahydrofuran-2β-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione ,  1-[(2R)-4α-(tert-Butyldimethylsilyl)-5β-(phenylsulfonyl)-5-(hydroxymethyl)tetrahydrofuran-2β-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione ,  3′-O,5′-O-Bis(tert-butyldimethylsilyl)-4′-allylthymidine ,  3′-O,5′-O-Bis(tert-butyldimethylsilyl)-4′-azidothymidine ,  3′-O,5′-O-Bis(tert-butyldimethylsilyl)-4′-methylthymidine ,  3′-O-(tert-Butyldimethylsilyl)-4′-(tert-butyldimethylsiloxymethyl)-5′-deoxythymidine ,  3′-O,5′-O-Bis(tert-butyldimethylsilyl)-4′-(phenylsulfonyl)thymidine ,  3′-O,5′-O-Bis(tert-butyldimethylsilyl)-4′-ethylthymidine ,  3′-O,5′-O-Diacetyl-4′-cyanothymidine

Terms in the title (4)： 脱離基 ,  求核置換 ,  置換 ,  チミジン