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J-GLOBAL ID：200902245177713362   Reference number：09A0450237

COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis

COUP-TFIIはWnt/β-カテニンシグナルの下流に作用し,PPARγ遺伝子発現をサイレンスし,脂肪生成を抑制する

Author (17)： OKAMURA Masashi (Univ. Tokyo, Tokyo, JPN) ,  OKAMURA Masashi (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  KUDO Hiromi (Univ. Tokyo, Tokyo, JPN) ,  WAKABAYASHI Ken-ichi (Univ. Tokyo, Tokyo, JPN) ,  TANAKA Toshiya (Univ. Tokyo, Tokyo, JPN) ,  NONAKA Aya (Univ. Tokyo, Tokyo, JPN) ,  UCHIDA Aoi (Univ. Tokyo, Tokyo, JPN) ,  TSUTSUMI Shuichi (Univ. Tokyo, Tokyo, JPN) ,  SAKAKIBARA Iori (Univ. Tokyo, Tokyo, JPN) ,  NAITO Makoto (Niigata Univ. Graduate School of Medical and Dental Sci., Niigata, JPN) ,  OSBORNE Timothy F. (Univ. California, CA) ,  HAMAKUBO Takao (Univ. Tokyo, Tokyo, JPN) ,  ITO Sadayoshi (Tohoku Univ. Graduate School of Medicine, Sendai, JPN) ,  ABURATANI Hiroyuki (Univ. Tokyo, Tokyo, JPN) ,  YANAGISAWA Masashi (Univ. Texas Southwestern Medical Center, TX) ,  KODAMA Tatsuhiko (Univ. Tokyo, Tokyo, JPN) ,  SAKAI Juro (Univ. Tokyo, Tokyo, JPN)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 106  Issue： 14  Page： 5819-5824  Publication year： Apr. 07, 2009 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,  *steroid hormone receptor ,  *transcription factor ,  *catenin ,  PPAR gamma ,  gene expression ,  *Lipogenesis ,  genetic technique ,  DNA microarray ,  immunoprecipitation ,  fat cell ,  cultured cell ,  cell ,  gene ,  peroxisome ,  mRNA ,  intron ,  *beta Catenin ,  Gene Expression Profiling ,  3T3 L1 Cells ,  preadipocyte ,  target gene ,  *Signal Transduction ,  *COUP Transcription Factor II ,  *Wnt Signaling Pathway ,  Gene Expression Regulation ,  Chromatin Immunoprecipitation ,  *Proteins ,  molecular genetic phenomenon ,  bioassay ,  immunoassay ,  Heredity
Semi thesaurus term： *cellular signal transduction ,  *COUP-TFII ,  *Wnt signaling pathway ,  Gene Expression Regulation ,  Chromatin Immunoprecipitation

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Biological function  (EB03040U)

Terms in the title (8)： COUP-TFII ,  Wnt ,  β-カテニン ,  シグナル ,  下流 ,  PPARγ遺伝子 ,  発現 ,  脂肪生成