Art

J-GLOBAL ID：200902245942612413   Reference number：05A0142556

Divergent Modes of Induction of Rat Hepatic and Pulmonary CYP3A1 by Dexamethasone and Pregnenolone 16α-Carbonitrile

デキサメタゾン及びプレグネノロン16α-カルボニトリルによるラット肝臓及び-肺のCYP3A1誘導様式

Author (3)： HOSOE T (Toho Univ., Chiba, JPN) ,  NAKAHAMA T (Toho Univ., Chiba, JPN) ,  INOUYE Y (Toho Univ., Chiba, JPN)
Material： Journal of Health Science  (J Health Sci)
Volume： 51  Issue： 1  Page： 75-79  Publication year： Feb. 01, 2005 
JST Material Number： S0030A  ISSN： 1344-9702  CODEN： JHSCFD  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *chemical substance ,...
Semi thesaurus term： CYP3A1

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JST classification (2)： Influence on animals  (EE05040R) ,  Toxicity of organic compounds  (GZ02030Y)

Substance index (2)： Dexamethasone ,  Pregnenolone

Reference (12)：

• 1) Schuetz, E. G. and Guzelian, P. S. (1984) Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. J. Biol. Chem., 259, 2007-2012.
• 2) Zhang, H., LeCulyse, E., Liu, L., Hu, M., Matoney, L., Zhu, W. and Yan, B. (1999) Rat Pregnane X Receptor: Molecular Cloning, Tissue Distribution, and Xenobiotic Regulation. Arch. Biochem. Biophys., 368, 14-22.
• 3) Huss, J. M. and Kasper, C. B. (2000) Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors. Mol. Pharmacol., 58, 48-57.
• 4) Pascussi, J.-M., Drocourt, L., Gerbal-Chaloin, S., Fabre, J.-M., Maurel, P. and Vilarem, M.-J. (2001) Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur. J. Biochem., 268, 6346-6357.
• 5) Mahnke, A., Strotkamp, D., Roos, P. H., Hanstein, W. G., Chabot, G. G. and Nef, P. (1997) Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Arch. Biochem. Biophys., 337, 62-68.

Terms in the title (8)： デキサメタゾン ,  プレグネノロン16α-カルボニトリル ,  ラット ,  肝臓 ,  肺 ,  CYP3A1 ,  誘導 ,  様式