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J-GLOBAL ID：200902246312881722   Reference number：08A0080251

siRNA-MEDIATED INHIBITION OF PHOSPHATIDYLINOSITOL GLYCAN CLASS B (PIGB) CONFERS RESISTANCE TO METHYLMERCURY IN HEK293 CELLS

siRNA媒介阻害ホスファチジルイノシトールグリカンクラスB(PIGB)はHEK293細胞でメチル水銀に対して抵抗を与える

Author (7)： HWANG Gi-wook (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  HAYASHI Tatsuya (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  KITA Kayoko (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  TAKAHASHI Tsutomu (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  KUGE Shusuke (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  NAGANUMA Akira (Lab. of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku Univ.) ,  NAGANUMA Akira (Tohoku Univ. 21st Century COE Program ′′Comprehensive Res. and Education Center for Planning of Drug Dev. and ...)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 32  Issue： 5  Page： 581-583 (J-STAGE)  Publication year： 2007 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *antisense RNA ,...

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JST classification (2)： Toxicity of metals and metal compounds  (GZ02022V) ,  Research methods in genetics  (EC01020N)

Substance index (1)： Methylmercury

Reference (4)：

• CASTOLDI, A. F. Neurotoxic and molecular effects of methylmercury in humans. Rev. Environ. Health. 2003, 18, 19-31
• CLARKSON, T. W. The three modern faces of mercury. Environ. Health Perspect. 2002, 110, Suppl. 1, 11-23
• PADDISON, P. J. A resource for large-scale RNA-interference-based screens in mammals. Nature. 2004, 428, 427-431
• TAKAHASHI, M. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. EMBO J. 1996, 15, 4254-4261

Terms in the title (4)： siRNA ,  阻害 ,  HEK293細胞 ,  メチル水銀