Art

J-GLOBAL ID：200902249612004773   Reference number：06A0374820

MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer

日本人と白人および結腸直腸癌と食道癌の日本人患者におけるMDR1ハプロタイプ頻度

Author (15)： KOMOTO Chiho (Kobe Univ., Kobe, JPN) ,  NAKAMURA Tsutomu (Kobe Univ., Kobe, JPN) ,  SAKAEDA Toshiyuki (Kobe Univ., Kobe, JPN) ,  SAKAEDA Toshiyuki (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  KROETZ Deanna L. (Univ. California San Francisco, CA, USA) ,  YAMADA Toshio (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OMATSU Hideaki (Kobe Univ., Kobe, JPN) ,  KOYAMA Tatsuya (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OKAMURA Noboru (Kobe Univ., Kobe, JPN) ,  MIKI Ikuya (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  TAMURA Takao (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  AOYAMA Nobuo (Kobe Univ., Kobe, JPN) ,  KASUGA Masato (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OKUMURA Katsuhiko (Kobe Univ., Kobe, JPN) ,  OKUMURA Katsuhiko (Kobe Univ. Graduate School of Medicine, Kobe, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 21  Issue： 2  Page： 126-132  Publication year： Apr. 27, 2006 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： ethnic difference ,...

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JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Structure and chemistry of genes  (EC02020U)

Reference (34)：

• 1) Sakaeda, T., Nakamura, T. and Okumura, K.: MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol. Pharm. Bull., 25: 1391-1400 (2002).
• 2) Sakaeda, T., Nakamura, T. and Okumura, K.: Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs. Pharmacogenomics, 4: 397-410 (2003).
• 3) Marzolini, C., Paus, E., Buclin, T. and Kim, R. B.: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin. Pharmacol. Ther., 75: 13-33 (2004).
• 4) Woodahl, E. L. and Ho, R. J.: The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function. Curr. Drug Metab., 5: 11-19 (2004).
• 5) Pauli-Magnus, C. and Kroetz, D. L.: Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1). Pharm. Res., 21: 904-913 (2004).

Terms in the title (8)： 日本人 ,  白人 ,  結腸直腸癌 ,  食道癌 ,  患者 ,  MDR1 ,  ハプロタイプ ,  頻度