Art

J-GLOBAL ID：200902249612004773   Reference number：06A0374820

MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer

日本人と白人および結腸直腸癌と食道癌の日本人患者におけるMDR1ハプロタイプ頻度

Author (15)： KOMOTO Chiho (Kobe Univ., Kobe, JPN) ,  NAKAMURA Tsutomu (Kobe Univ., Kobe, JPN) ,  SAKAEDA Toshiyuki (Kobe Univ., Kobe, JPN) ,  SAKAEDA Toshiyuki (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  KROETZ Deanna L. (Univ. California San Francisco, CA, USA) ,  YAMADA Toshio (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OMATSU Hideaki (Kobe Univ., Kobe, JPN) ,  KOYAMA Tatsuya (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OKAMURA Noboru (Kobe Univ., Kobe, JPN) ,  MIKI Ikuya (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  TAMURA Takao (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  AOYAMA Nobuo (Kobe Univ., Kobe, JPN) ,  KASUGA Masato (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OKUMURA Katsuhiko (Kobe Univ., Kobe, JPN) ,  OKUMURA Katsuhiko (Kobe Univ. Graduate School of Medicine, Kobe, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 21  Issue： 2  Page： 126-132  Publication year： Apr. 27, 2006 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： ethnic difference ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=06A0374820&from=J-GLOBAL&jstjournalNo=X0758A") }}

JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Structure and chemistry of genes  (EC02020U)

Reference (34)：

• 1) Sakaeda, T., Nakamura, T. and Okumura, K.: MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol. Pharm. Bull., 25: 1391-1400 (2002).
• 2) Sakaeda, T., Nakamura, T. and Okumura, K.: Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs. Pharmacogenomics, 4: 397-410 (2003).
• 3) Marzolini, C., Paus, E., Buclin, T. and Kim, R. B.: Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin. Pharmacol. Ther., 75: 13-33 (2004).
• 4) Woodahl, E. L. and Ho, R. J.: The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function. Curr. Drug Metab., 5: 11-19 (2004).
• 5) Pauli-Magnus, C. and Kroetz, D. L.: Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1). Pharm. Res., 21: 904-913 (2004).

Terms in the title (8)： 日本人 ,  白人 ,  結腸直腸癌 ,  食道癌 ,  患者 ,  MDR1 ,  ハプロタイプ ,  頻度