Art

J-GLOBAL ID：200902249735030760   Reference number：06A0663044

Synthetic Approaches to Bridgehead Nitrogen Methanesulfonamide Derivatives of 3-Amino-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones, Potential COX-2 Selective Inhibitors

COX-2選択的阻害剤候補である3-アミノ-2-チオキソ-2,3-ジヒドロチエノ[2,3-d]ピリミジン-4(1H)-オン類の橋頭位窒素メタンスルホンアミド誘導体の合成法

Author (7)： GRANATA Giuseppe (Univ. Catania, Catania, ITA) ,  BARBAGALLO Salvatore (Univ. Catania, Catania, ITA) ,  PERDICARO Antonio (Univ. Catania, Catania, ITA) ,  MARRAZZO Agostino (Univ. Catania, Catania, ITA) ,  SANTAGATI Andrea (Univ. Catania, Catania, ITA) ,  LOMBARDO Laura (Univ. Catania, Catania, ITA) ,  CARDILE Venera (Univ. Catania, Catania, ITA)
Material： Journal of Heterocyclic Chemistry  (J Heterocycl Chem)
Volume： 43  Issue： 4  Page： 1099-1104  Publication year： Jul. 2006 
JST Material Number： B0720A  ISSN： 0022-152X  CODEN： JHTCAD  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： cyclooxygenase ,...
Semi thesaurus term： COX-2 selective inhibitor

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=06A0663044&from=J-GLOBAL&jstjournalNo=B0720A") }}

JST classification (2)： Pyrimidines  (CF07103W) ,  Enzyme in general  (EB09010D)

Substance index (16)： 1-Iodo-2,4-dinitrobenzene ,  2-Iodobenzoic acid ,  Iodocyclohexane ,  2-Isothiocyanato-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid ethyl ester ,  Methanesulfonylhydrazine ,  N-[2-Thioxo-4-oxo-1,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-3(2H)-yl]methanesulfonamide ,  N-[1,2-Dihydro-2-thioxo-4-oxo-5,6-dimethylthieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide ,  N-[2-(Cyclohexylthio)-4-oxo-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide ,  N-[2-(Cyclohexylthio)-4-oxo-5,6-dimethylthieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide ,  2,4-Difluoro-1-iodobenzene ,  2-[[3-[(Methylsulfonyl)amino]-4-oxo-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-yl]thio]benzoic acid ,  2-[[3-[(Methylsulfonyl)amino]-4-oxo-5,6-dimethylthieno[2,3-d]pyrimidine-2-yl]thio]benzoic acid ,  N-[2-[(2,4-Dinitrophenyl)thio]-4-oxo-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide ,  N-[2-[(2,4-Dinitrophenyl)thio]-4-oxo-5,6-dimethylthieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide ,  N-[2-[(2,4-Difluorophenyl)thio]-4-oxo-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide ,  N-[2-[(2,4-Difluorophenyl)thio]-4-oxo-5,6-dimethylthieno[2,3-d]pyrimidine-3(4H)-yl]methanesulfonamide

Terms in the title (6)： COX-2選択的阻害剤 ,  ピリミジン ,  窒素 ,  メタン ,  スルホンアミド誘導体 ,  合成法