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J-GLOBAL ID：200902250525218528   Reference number：04A0729327

Insulinomimetic Vanadyl-Hydroxythiazolethione Complexes with VO(S₂O₂) Coordination Mode: The Correlation between the Activity and Hammett’s Substituent Constant

VO(S₂O₂)配位様式をとるインシュリン模擬バナジル-ヒドロキシチアゾールチオン錯体 活性とHammettの置換基定数の相関

Author (5)： KATOH A (Seikei Univ., Tokyo) ,  YAMAGUCHI M (Seikei Univ., Tokyo) ,  SAITO R (Seikei Univ., Tokyo) ,  ADACHI Y (Kyoto Pharmaceutical Univ., Kyoto) ,  SAKURAI H (Kyoto Pharmaceutical Univ., Kyoto)
Material： Chemistry Letters  (Chem Lett)
Volume： 33  Issue： 10  Page： 1274-1275  Publication year： Oct. 05, 2004 
JST Material Number： S0742A  ISSN： 0366-7022  CODEN： CMLTAG  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： chemical synthesis ,...
Semi thesaurus term： substituent constant ,...

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JST classification (2)： 4A and 5A groups  (CE01070U) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (9)： 4'-Nitroacetophenone ,  4'-Chloroacetophenone ,  4'-Methoxyacetophenone ,  Acetophenone ,  Potassium ethyl xanthogenate ,  3-Hydroxy-4-(4-nitrophenyl)thiazole-2(3H)-thione ,  3-Hydroxy-4-(4-chlorophenyl)thiazole-2(3H)-thione ,  3-Hydroxy-4-phenylthiazole-2(3H)-thione ,  3-Hydroxy-4-(4-methoxyphenyl)thiazole-2(3H)-thione

Reference (21)：

• 1) WHO, Diabetes Mellitus, Reports of a WHO Study Group, WHO Technical Report Series (1985), p 727, 876.
• 2) S. Patel, in “Diabetes in Focus,” 2nd ed., Pharmaceutical Press (2003), p 79.
• 3) a) H. Sakurai and A. Tsuji, in “Vanadium in the Environment, Part II,” ed. by J. O. Nriagu, John Wiley & Sons, New York (1998), p 297.
•  b) H. Sakurai, Chem. Rec., 2, 237 (2002);
•  H. Sakurai, Y. Kojima, Y. Yoshikawa, K. Kawabe, and H. Yasui, Coord. Chem. Rev., 226, 187 (2002).

Terms in the title (5)： 配位様式 ,  インシュリン ,  錯体 ,  活性 ,  相関