Art

J-GLOBAL ID：200902250799850093   Reference number：09A0478392

A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

環状デプシペプチドHDAC阻害剤スピルコスタチンAの固相全合成

Author (8)： IIJIMA Yusuke (Dep. of Applied Chemistry, Tokyo Inst. of Technol., 2-12-1, Ookayama, Meguro, Tokyo 152-8552, JPN) ,  MUNAKATA Asami (Dep. of Applied Chemistry, Tokyo Inst. of Technol., 2-12-1, Ookayama, Meguro, Tokyo 152-8552, JPN) ,  MUNAKATA Asami (Japan Biological Informatics Consortium (JBIC), 2-45 Aomi, Koto-ku, Tokyo 135-8073, JPN) ,  SHIN-YA Kazuo (National Inst. of Advanced Industrial Sci. and Technol., 2-42, Aomi, Koto-ku, Tokyo 135-0064, JPN) ,  GANESAN A. (School of Chemistry, Univ. of Southampton, Southampton SO17 1BJ, GBR) ,  DOI Takayuki (Dep. of Applied Chemistry, Tokyo Inst. of Technol., 2-12-1, Ookayama, Meguro, Tokyo 152-8552, JPN) ,  DOI Takayuki (Graduate School of Pharmaceutical Sciences, Tohoku Univ., Aza-Aoba, Aramaki, Aoba, Sendai 980-8578, JPN) ,  TAKAHASHI Takashi (Dep. of Applied Chemistry, Tokyo Inst. of Technol., 2-12-1, Ookayama, Meguro, Tokyo 152-8552, JPN)
Material： Tetrahedron Letters  (Tetrahedron Lett)
Volume： 50  Issue： 24  Page： 2970-2972  Publication year： Jun. 17, 2009 
JST Material Number： E0366A  ISSN： 0040-4039  Document type： Article
Article type： 短報  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： total synthesis ,  solid phase synthesis ,  *depsipeptide ,  cyclopeptide ,  enzyme inhibitor ,  amide hydrolase ,  liquid phase reaction ,  lactonization ,  macrocyclic compound
Semi thesaurus term： HDAC inhibitor ,  マクロラクトン化

JST classification (1)： Peptides  (CF10080G)

Substance index (5)： (3S,4R)-3-Hydroxy-4-(9H-fluorene-9-ylmethoxycarbonylamino)-5-methylhexanoic acid ,  (S)-3-Hydroxy-7-(tritylthio)-4-heptenoic acid ,  N-(9H-Fluoren-9-ylmethoxycarbonyl)-D-alanine ,  N-Fmoc-S-Trt-D-Cysteine ,  Spiruchostatin A

Terms in the title (6)： 環状 ,  デプシペプチド ,  HDAC阻害剤 ,  スピルコスタチンA ,  固相 ,  全合成