Art

J-GLOBAL ID：200902252682653346   Reference number：09A1054725

Enzyme-catalyzed resolution of 3,8-dioxatricyclo[3.2.1.0^2,4]octane-6-carboxylic esters and the application to the synthesis of 3-epishikimic acid

3,8-ジオキサトリシクロ[3.2.1.0^2,4]オクタン-6-カルボン酸エステル類の酵素触媒による分割

Author (8)： HAMADA Manabu (Dep. of Applied Chemistry, Keio Univ., 3-14-1 Hiyoshi, Yokohama 223-8522, JPN) ,  INAMI Yoshikazu (Fac. of Pharmacy, Keio Univ., 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, JPN) ,  NAGAI Yasuhito (Dep. of Chemistry, Keio Univ., 3-14-1 Hiyoshi, Yokohama 223-8522, JPN) ,  HIGASHI Toshinori (Fac. of Pharmacy, Keio Univ., 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, JPN) ,  SHOJI Mitsuru (Fac. of Pharmacy, Keio Univ., 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, JPN) ,  OGAWA Seiichiro (Dep. of Bioscience and Bioinformatics, Keio Univ., 3-14-1 Hiyoshi, Yokohama 223-8522, JPN) ,  UMEZAWA Kazuo (Dep. of Applied Chemistry, Keio Univ., 3-14-1 Hiyoshi, Yokohama 223-8522, JPN) ,  SUGAI Takeshi (Fac. of Pharmacy, Keio Univ., 1-5-30, Shibakoen, Minato-ku, Tokyo 105-8512, JPN)
Material： Tetrahedron: Asymmetry  (Tetrahedron Asym)
Volume： 20  Issue： 18  Page： 2105-2111  Publication year： Sep. 23, 2009 
JST Material Number： T0907A  ISSN： 0957-4166  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *carboxylate (ester) ,  optical resolution ,  enzymatic resolution ,  racemic modification ,  alditol ,  biological activity ,  organic substance ,  hydrophobic ,  hydrophilicity ,  ester bond hydrolase ,  antiviral drug ,  oxygen heterocyclic compound ,  aliphatic carboxylic acid ,  vinyl compound ,  unsaturated carboxylic acid ,  olefin compound ,  unsaturated alcohol ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy acid ,  polyol ,  Carbasugars ,  kinetic resolution ,  natural organic matter
Semi thesaurus term： esterase ,  kinetic resolution ,  organic natural product

JST classification (3)： Aliphatic carboxylic esters,anhydrides,acid halides,acyl peroxides  (CF03210P) ,  Other separation methods  (CC01060D) ,  Applications of enzymes  (EB09100B)

Substance index (16)： Oseltamivir ,  (3S)-3α,4β,5α-Trihydroxy-1-cyclohexene-1-carboxylic acid ,  Furan ,  Acrylic acid ,  (1α,4α)-7-Oxabicyclo[2.2.1]heptane-2β-carboxylic acid ,  rac-(1β^*,4β^*)-5β^*-Iodo-6α^*-hydroxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid lactone ,  rac-(1β^*,4β^*)-5α^*,6α^*-Epoxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid ethyl ester ,  rac-(1β^*,4β^*)-5α^*,6α^*-Epoxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid methyl ester ,  rac-(1β^*,4β^*)-5α^*,6α^*-Epoxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid chloromethyl ester ,  rac-(1β^*,4β^*)-5α^*,6α^*-Epoxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid 2-chloroethyl ester ,  rac-(1β^*,4β^*)-5α^*,6α^*-Epoxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid 2-oxo-2-(dimethylamino)ethyl ester ,  rac-(1β^*,4β^*)-5α^*,6α^*-Epoxy-7-oxabicyclo[2.2.1]heptane-2α^*-carboxylic acid 2,2,2-trifluoroethyl ester ,  (1α,4α)-5β,6β-Epoxy-7-oxabicyclo[2.2.1]heptane-2β-carboxylic acid ,  (1α,6α)-5α-Hydroxy-7-oxabicyclo[4.1.0]hepta-2-ene-3-carboxylic acid methyl ester ,  (1β,6β)-5β-Hydroxy-7-oxabicyclo[4.1.0]hepta-2-ene-3-carboxylic acid 2-chloroethyl ester ,  Shikimic Acid

Terms in the title (3)： オクタン ,  カルボン酸エステル ,  酵素触媒