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J-GLOBAL ID：200902256557593779   Reference number：09A0154510

Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects

日本人のヒトII型アルコールデヒドロゲナーゼ(ADH4)遺伝子プロモーター領域の多型は転写活性とエタノール代謝の両方に影響する

Author (6)： KIMURA Yukiko (Dep. of Hygiene, Kanazawa Univ. Graduate School of Medical Sci.) ,  NISHIMURA Fusae T. (Dep. of Hygiene, Kanazawa Univ. Graduate School of Medical Sci.) ,  ABE Shuntaro (Dep. of Forensic Medicine, The Jikei Univ. School of Medicine) ,  FUKUNAGA Tatsushige (Tokyo Medical Examiner’s Office, Tokyo Metropolitan Government) ,  TANII Hideji (Dep. of Hygiene, Kanazawa Univ. Graduate School of Medical Sci.) ,  SAIJOH Kiyofumi (Dep. of Hygiene, Kanazawa Univ. Graduate School of Medical Sci.)
Material： Journal of Toxicological Sciences  (J Toxicol Sci)
Volume： 34  Issue： 1  Page： 89-97 (J-STAGE)  Publication year： 2009 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Japan ,...
Semi thesaurus term： transcriptional activity

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JST classification (2)： Toxicology in general  (GZ01000K) ,  Genetic variation  (EC01030Y)

Substance index (1)： Ethanol

Reference (32)：

• BACH, I. More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. EMBO. J. 1993, 12, 4229-4242
• BARRETT, J. C. Haploview : analysis and visualization of LD and haplotype maps. Bioinformatics. 2005, 21, 263-265
• BOSRON, W. F. Human liver pi-alcohol dehydrogenase : kinetic and molecular properties. Biochemistry. 1979, 18, 1101-1105
• CHOU, W. Y. An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2) : effects of the sequence variant on transcription factor binding and promoter strength. Alcohol. Clin. Exp. Res. 1999, 23, 963-968
• DITLOW, C. C. Physical and enzymatic properties of a class II alcohol dehydrogenase isozyme of human liver : pi-ADH. Biochemistry. 1984, 23, 6363-6368

Terms in the title (8)： 日本人 ,  ヒト ,  アルコールデヒドロゲナーゼ ,  遺伝子 ,  プロモーター領域 ,  多型 ,  転写活性 ,  エタノール代謝