Art

J-GLOBAL ID：200902257865163870   Reference number：03A0491629

Human Pituitary Adenomas Infrequently Contain Inactivation of Retinoblastoma 1 Gene and Activation of Cyclin Dependent Kinase 4 Gene

ヒト下垂体腺腫は稀に網膜芽腫1遺伝子の不活化とサイクリン依存性キナーゼの活性化を含んでいる

Author (7)： HONDA S (Univ. Tokushima, Tokushima, JPN) ,  TANAKA(KOSUGI) C (Univ. Tokushima, Tokushima, JPN) ,  YAMADA S (Toranomon Hospital, Tokyo, JPN) ,  SANO T (Univ. Tokushima, Tokushima, JPN) ,  MATSUMOTO T (Univ. Tokushima, Tokushima, JPN) ,  ITAKURA M (Univ. Tokushima, Tokushima, JPN) ,  YOSHIMOTO K (Univ. Tokushima, Tokushima, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 50  Issue： 3  Page： 309-318  Publication year： Jun. 2003 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： tumorigenesis ,...

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JST classification (3)： Tumors(=neoplasms)of endocrine system  (GL04000P) ,  Structure and chemistry of genes  (EC02020U) ,  Enzyme in general  (EB09010D)

Reference (29)：

• 1. Adams PD (2001) Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim Biophys Acta 1471: M123-M133.
• 2. Hibberts NA, Simpson DJ, Bicknell JE, Broome JC, Hoban PR, Clayton RN, Farrell WE (1999) Analysis of cyclin D1 (CCND1) allelic imbalance and overexpression in sporadic human pituitary tumors. Clin Cancer Res 5: 2133-2139.
• 3. Woloschak M, Yu A, Post KD (1997) Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation. Mol Carcinog 19: 221-224.
• 4. Horowitz JM, Park SH, Bogenmann E, Cheng JC, Yandell DW, Kaye FJ, Minna JD, Dryja TP, Weinberg RA (1990) Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells. Proc Natl Acad Sci USA 87: 2775-2779.
• 5. Ikeda H, Beauchamp RL, Yoshimoto T, Yandell DW (1995) Detection of heterozygous mutation in the retinoblastoma gene in a human pituitary adenoma using PCR-SSCP analysis and direct sequencing. Endocrine Pathol 6: 189-196.

Terms in the title (7)： ヒト ,  下垂体腺腫 ,  網膜芽腫 ,  遺伝子 ,  不活化 ,  サイクリン依存性キナーゼ ,  活性化