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J-GLOBAL ID：200902258689768376   Reference number：07A0922830

Promotion of IL-8 production in PMA-stimulated HL-60 cells by sesquiterpene quinones from a marine sponge, Hippospongia sp.

海綿Hippospongia sp.由来のセスキテルペンキノン類によるPMA刺激HL-60細胞でのIL-8産生の促進

Author (7)： ODA Taiko (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  WANG Weifang (Tokyo Univ. Marine Sci. and Technol., Tokyo, JPN) ,  WANG Weifang (Tohoku Pharmaceutical Univ., Sendai, JPN) ,  FUJITA Ayako (Tokyo Univ. Marine Sci. and Technol., Tokyo, JPN) ,  MOCHIZUKI Masataka (Kyoritsu Univ. Pharmacy, Tokyo, JPN) ,  UKAI Kazuyo (Tohoku Pharmaceutical Univ., Sendai, JPN) ,  NAMIKOSHI Michio (Tohoku Pharmaceutical Univ., Sendai, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 61  Issue： 4  Page： 434-437  Publication year： 2007 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *Porifera ,...
Semi thesaurus term： *Hippospongia sp. ,...

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JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (8)： Phorbol 12-myristate 13-acetate ,  Ilimaquinone ,  Smenospongidine ,  5-epi-Smenospongidine ,  Smenospongiarine ,  5-epi-Smenospongiarine ,  Smenospongine ,  5-epi-Smenospongine

Reference (26)：

• LUIBRAND, RT. Ilimaquinone, a sesquiterpenoid quinone from a marine sponge. Tetrahedron. 1979, 35, 609-612
• CAPON, RJ. A revision of the absolute stereochemistry of illimaquinone. J Org Chem. 1987, 52, 5059-5060
• CARTE, B. 5-epi-Ilimaquinone, a metabolite of the sponge Fenestraspongia sp. J Org Chem. 1985, 50, 2785-2787
• RODRIGUEZ, J. The structures and stereochemistry of cytotoxic sesquiterpene quinones from Dactylospongia elegans. Tetrahedron. 1992, 48, 6667-6680
• KONDRACKI, ML. Biologically active quinone and hydroquinone sesquiterpenoids from the sponge Smenospongia sp. Tetrahedron. 1989, 45, 1995-2004

Terms in the title (8)： 海綿 ,  セスキテルペン ,  キノン類 ,  PMA ,  刺激 ,  HL-60細胞 ,  IL-8 ,  促進