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J-GLOBAL ID：200902259269254187   Reference number：08A0320217

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

有力な薬物標的としてのTrypanosoma bruceiジヒドロオロテートデヒドロゲナーゼの特性化;構造,速度論及びRNAi研究

Author (21)： ARAKAKI Tracy L. (Univ. Washington, WA, USA) ,  ARAKAKI Tracy L. (Structural Genomics of Pathogenic Protozoa) ,  BUCKNER Frederick S. (Structural Genomics of Pathogenic Protozoa) ,  BUCKNER Frederick S. (Univ. Washington, WA, USA) ,  GILLESPIE J. Robert (Univ. Washington, WA, USA) ,  MALMQUIST Nicholas A. (Univ. Texas Southwestern Medical Center, TX, USA) ,  PHILLIPS Margaret A. (Univ. Texas Southwestern Medical Center, TX, USA) ,  KALYUZHNIY Oleksandr (Univ. Washington, WA, USA) ,  KALYUZHNIY Oleksandr (Structural Genomics of Pathogenic Protozoa) ,  LUFT Joseph R. (Structural Genomics of Pathogenic Protozoa) ,  LUFT Joseph R. (Hauptman Woodward Inst., NY, USA) ,  DETITTA George T. (Structural Genomics of Pathogenic Protozoa) ,  DETITTA George T. (Hauptman Woodward Inst., NY, USA) ,  VERLINDE Christophe L. M. J. (Univ. Washington, WA, USA) ,  VERLINDE Christophe L. M. J. (Structural Genomics of Pathogenic Protozoa) ,  VAN VOORHIS Wesley C. (Structural Genomics of Pathogenic Protozoa) ,  VAN VOORHIS Wesley C. (Univ. Washington, WA, USA) ,  HOL Wim G. J. (Univ. Washington, WA, USA) ,  HOL Wim G. J. (Structural Genomics of Pathogenic Protozoa) ,  MERRITT Ethan A. (Univ. Washington, WA, USA) ,  MERRITT Ethan A. (Structural Genomics of Pathogenic Protozoa)
Material： Molecular Microbiology  (Mol Microbiol)
Volume： 68  Issue： 1  Page： 37-50  Publication year： Apr. 2008 
JST Material Number： T0455A  ISSN： 0950-382X  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *Trypanosoma brucei ,  product development ,  drug ,  *dehydrogenase ,  RNA interference ,  gene manipulation ,  biosynthesis ,  uptake ,  *enzyme inhibitor ,  *combination therapy ,  Eukaryota ,  human ,  *crystal structure ,  resolving power ,  selectivity ,  species specificity ,  nitrogen heterocyclic compound ,  organofluorine compound ,  urea compound ,  hydroxy compound ,  Gene Knockdown Technique ,  Drug Discovery ,  *microorganism ,  *protozoa ,  *Mastigophora ,  *Zoomastigophora ,  Heredity ,  organism
Semi thesaurus term： antagonist ,  *ジヒドロオロテートデヒドロゲナーゼ ,  knockdown ,  resolution ,  drug development

JST classification (4)： Enzyme in general  (EB09010D) ,  Enzyme physiology  (EG03052C) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Infectious diseases,parasitics diseases in general.  (GD01010H)

Substance index (2)： Fluorouracil ,  Pyrimidine

Terms in the title (6)： 薬物標的 ,  Trypanosoma ,  特性化 ,  速度論 ,  RNAi ,  研究