Art

J-GLOBAL ID：200902259278050535   Reference number：09A0741749

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

加齢期のラパマイシンの摂取は,遺伝的に多様なマウスの寿命を延長させる

Author (14)： HARRISON David E. (Jackson Lab., Maine, USA) ,  STRONG Randy (Univ. Texas Health Sci. Center at San Antonio, Texas, USA) ,  SHARP Zelton Dave (Univ. Texas Health Sci. Center at San Antonio, Texas, USA) ,  NELSON James F. (Univ. Texas Health Sci. Center at San Antonio, Texas, USA) ,  ASTLE Clinton M. (Jackson Lab., Maine, USA) ,  FLURKEY Kevin (Jackson Lab., Maine, USA) ,  NADON Nancy L. (National Inst. on Aging, Maryland, USA) ,  WILKINSON J. Erby (Univ. Michigan School of Medicine, Michigan, USA) ,  FRENKEL Krystyna (NY Univ. School of Medicine, New York, USA) ,  CARTER Christy S. (Wake Forest Univ. School of Medicine, North Carolina, USA) ,  PAHOR Marco (Wake Forest Univ. School of Medicine, North Carolina, USA) ,  JAVORS Martin A. (Univ. Texas Health Sci. Center at San Antonio, Texas, USA) ,  FERNANDEZ Elizabeth (Univ. Texas Health Sci. Center at San Antonio, Texas, USA) ,  MILLER Richard A. (Univ. Michigan, Michigan, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 460  Issue： 7253  Page： 392-395  Publication year： Jul. 16, 2009 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： mouse(animal) ,  serine-threonine kinase ,  *cellular signal transduction ,  lifetime ,  death ,  aging(physiology) ,  senile change ,  lifetime extension ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone ,  enzyme inhibitor
Semi thesaurus term： *mTOR

JST classification (2)： Cell physiology in general  (EF02010S) ,  Aging and death  (EJ16040S)

Substance index (1)： Rapamycin

Terms in the title (5)： 加齢 ,  ラパマイシン ,  遺伝 ,  マウス ,  寿命