Art

J-GLOBAL ID：200902259556623924   Reference number：03A0472067

Synthetic Approaches toward Ecteinascidins. Part 2. Preparation of the ABCDE Ring System of Ecteinascidins Having Characteristic Substituents in Both Benzene Rings

エクテイナシジン類に向けての合成アプローチ 2 両ベンゼン環に特徴的置換基を持つエクテイナシジン類のABCDE環系の合成

Author (5)： SAITO N (Meiji Pharmaceutical Univ., Tokyo, JPN) ,  SEKI R (Meiji Pharmaceutical Univ., Tokyo, JPN) ,  KAMEYAMA N (Meiji Pharmaceutical Univ., Tokyo, JPN) ,  SUGIMOTO R (Meiji Pharmaceutical Univ., Tokyo, JPN) ,  KUBO A (Meiji Pharmaceutical Univ., Tokyo, JPN)
Material： Chemical and Pharmaceutical Bulletin  (Chemical & Pharmaceutical Bulletin)
Volume： 51  Issue： 7  Page： 821-831  Publication year： Jul. 01, 2003 
JST Material Number： G0504A  ISSN： 0009-2363  CODEN： CPBTAL  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...
Semi thesaurus term： bridged compound ,...

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JST classification (1)： Pyrazines  (CF07104N)

Substance index (25)： Trabectedin ,  ET-770 ,  (2E)-2-[(6-Benzyloxy-7-methyl-1,3-benzodioxol-5-yl)methylene]-3-benzyl-7,9,10-trimethoxy-8,11-dimethyl-2,3,5,6-tetrahydro-1β,5β-epimino-3-benzazocin-4(1H)-one ,  (1R)-3,8,11-Trimethyl-9-methoxy-10-hydroxy-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-4-one ,  1-Acetyl-3-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzylidene)piperazine-2,5-dione ,  1-Acetyl-3-[2-bromo-3-methyl-4-methoxy-5-(methoxymethoxy)benzylidene]piperazine-2,5-dione ,  1-Acetyl-3-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzyl)piperazine-2,5-dione ,  1-Acetyl-3-[2-bromo-3-methyl-4-methoxy-5-(methoxymethoxy)benzyl]piperazine-2,5-dione ,  1,4-Diacetyl-3-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzyl)piperazine-2,5-dione ,  1,4-Diacetyl-3-[2-bromo-3-methyl-4-methoxy-5-(methoxymethoxy)benzyl]piperazine-2,5-dione ,  6-Hydroxy-7-methyl-1,3-benzodioxole-5-carbaldehyde ,  6-(Tosyloxy)-7-methyl-1,3-benzodioxole-5-carbaldehyde ,  1-Acetyl-3-[(Z)-6-(tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethylene]-6-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzyl)piperazine-2,5-dione ,  1-Acetyl-3-[(Z)-6-(tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethylene]-6-[2-bromo-3-methyl-4-methoxy-5-(methoxymethoxy)benzyl]piperazine-2,5-dione ,  2,5-Dioxo-3-[(Z)-6-(tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethylene]-4-benzyl-6-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzyl)piperazine-1-carboxylic acid isopropyl ester ,  2,5-Dioxo-3-[(Z)-6-(tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethylene]-4-benzyl-6-[2-bromo-3-methyl-4-methoxy-5-(methoxymethoxy)benzyl]piperazine-1-carboxylic acid isopropyl ester ,  2-Hydroxy-3-[(Z)-6-(tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethylene]-4-benzyl-5-oxo-6-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzyl)piperazine-1-carboxylic acid isopropyl ester ,  2-Hydroxy-3-[(Z)-6-(tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethylene]-4-benzyl-5-oxo-6-[2-bromo-3-methyl-4-methoxy-5-(methoxymethoxy)benzyl]piperazine-1-carboxylic acid isopropyl ester ,  (1R)-2-[(E)-[6-(Tosyloxy)-7-methyl-1,3-benzodioxole-5-yl]methylene]-3-benzyl-4-oxo-8-methyl-9-methoxy-10-hydroxy-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-11-carboxylic acid isopropyl ester ,  (1R)-2-[(E)-[6-(Tosyloxy)-7-methyl-1,3-benzodioxole-5-yl]methylene]-4-oxo-8-methyl-9-methoxy-10-hydroxy-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-11-carboxylic acid isopropyl ester ,  (1R)-2α-[6-(Tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethyl]-8,11-dimethyl-9-methoxy-10-(methoxymethoxy)-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine ,  (1R)-2α-[6-(Tosyloxy)-7-methyl-1,3-benzodioxole-5-ylmethyl]-8,11-dimethyl-9-methoxy-1,2,3,4,5,6-hexahydro-1β,5β-epimino-3-benzazocine-10-ol ,  (6S)-2-Methoxy-3,12,16-trimethyl-10,11-(methylenedioxy)-13-(tosyloxy)-6β,7,9,14,14aα,15β-hexahydro-6,15-epimino-5H-isoquino[3,2-b][3]benzazocine-1-ol ,  1-Benzyl-2-oxo-3-(2-bromo-3-methyl-4-methoxy-5-isopropoxybenzyl)-5,6-(methylenedioxy)-7-methyl-8-(tosyloxy)-2,3,4,9-tetrahydro-1H-indeno[1,2-b]pyrazine-4-carboxylic acid isopropyl ester ,  1-Benzyl-2-oxo-3-(3-methyl-4-methoxy-5-isopropoxybenzyl)-5,6-(methylenedioxy)-7-methyl-8-(tosyloxy)-2,3,4,9-tetrahydro-1H-indeno[1,2-b]pyrazine-4-carboxylic acid isopropyl ester

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Terms in the title (3)： ベンゼン環 ,  置換基 ,  環