Art

J-GLOBAL ID：200902259897777903   Reference number：08A0657350

Lupane triterpenes with a carbonyl group at C-20 induce cancer cell apoptosis

C-20にカルボニル基を有するルパントリテルペンは,癌細胞のアポトーシスを誘導する

Author (7)： HATA Keishi (Akita Prefectural Agricultural, Forestry, and Fisheries Res. Center, Akita, JPN) ,  OGAWA Shoujiro (Nihon Univ., Tokyo, JPN) ,  MAKINO Mitsuko (Nihon Univ., Tokyo, JPN) ,  MUKAIYAMA Toshiyuki (Sakamoto Bio Co., Ltd., Akita, JPN) ,  HORI Kazuyuki (Akita Prefectural Agricultural, Forestry, and Fisheries Res. Center, Akita, JPN) ,  IIDA Takashi (Nihon Univ., Tokyo, JPN) ,  FUJIMOTO Yasuo (Nihon Univ., Tokyo, JPN)
Material： Journal of Natural Medicines  (J Nat Med)
Volume： 62  Issue： 3  Page： 332-335  Publication year： 2008 
JST Material Number： L5856A  ISSN： 1340-3443  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： IC50

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JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic oncology in general  (GE02010R)

Substance index (5)： Lupeol ,  Lupeol acetate ,  3β-Acetoxy-30-norlupa-20-one ,  3β-Acetoxylupa-20(29)-ene-30-al ,  3β-Acetoxylupane-29-oic acid

Reference (8)：

• TAKASAKI, M. Anti-carcinogenic activity of Taraxacum plant. II. Biol Pharm Bull. 1999, 22, 606-610
• REICO, MC. Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Med. 1995, 61, 182-185
• YOU, YJ. Antiangiogenic activity of lupeol from Bombax ceiba. Phytother Res. 2003, 17, 341-344
• SALEEM, M. Lupeol modulates NF-kB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice. Oncogene. 2004, 23, 5203-5214
• HATA, K. Differentiation-inducing activity of lupane triterpenes on a mouse melanoma cell line. Cytotechnology. 2006, 52, 151-158

Terms in the title (4)： カルボニル基 ,  癌細胞 ,  アポトーシス ,  誘導