Art

J-GLOBAL ID：200902260964316965   Reference number：04A0042079

Human Pituitary Tumor Transforming Gene (hPTTG) Inhibits Human Lung Cancer A549 Cell Growth through Activation of p21^WAF1/CIP1

ヒト下垂体腫よう形質転換遺伝子(hPTTG)はp21^WAF1/CIP1の活性化を介してヒト肺癌A549細胞の増殖を阻害する

Author (9)： MU Y-M (Kyushu Univ., Fukuoka, JPN) ,  OBA K (Kyushu Univ., Fukuoka, JPN) ,  YANASE T (Kyushu Univ., Fukuoka, JPN) ,  ITO T (Kyushu Univ., Fukuoka, JPN) ,  ASHIDA K (Kyushu Univ., Fukuoka, JPN) ,  GOTO K (Kyushu Univ., Fukuoka, JPN) ,  MORINAGA H (JST-CREST, Kawaguchi, JPN) ,  IKUYAMA S (Kyushu Univ., Beppu, JPN) ,  TAKAYANAGI R (Kyushu Univ., Fukuoka, JPN)
Material： Endocrine Journal  (Endocr J)
Volume： 50  Issue： 6  Page： 771-781  Publication year： Dec. 2003 
JST Material Number： F0625A  ISSN： 0918-8959  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： 下垂体腫よう形質転換遺伝子 ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=04A0042079&from=J-GLOBAL&jstjournalNo=F0625A") }}

JST classification (2)： Cell division and proliferation  (EF02020D) ,  Gene expression  (EC02040Q)

Reference (27)：

• 1. Pei L, Melmed S (1997) Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol 11: 433-441.
• 2. Zhang X, Horwitz GA, Prezant TR, Valentini A, Nakashima M, Bronstein MD, Melmed S (1999) Structure, expression, and function of human pituitary tumor-transforming gene (PTTG). Mol Endocrinol 13: 156-166.
• 3. Dominguez A, Ramos-Morales F, Romero F, Rios RM, Dreyfus F, Tortolero M, Pintor-Toro, JA (1998) hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG. Oncogene 17: 2187-2193.
• 4. Lee IA, Seong C, Choe IS (1999) Cloning and expression of human cDNA encoding human homologue of pituitary tumor transforming gene. Biochem Mol Biol Int 47: 891-897.
• 5. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S (1999) Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 5: 1317-1321.

Terms in the title (8)： ヒト ,  下垂体腫よう ,  CIP1 ,  活性化 ,  肺癌 ,  A549細胞 ,  増殖 ,  阻害