Art

J-GLOBAL ID：200902261138846865   Reference number：03A0835552

Design and Synthesis of Orally Active Inhibitors of TNF Synthesis as Anti-rheumatoid Arthritis Drugs

経口活性なTNF阻害剤の設計と合成 抗慢性関節リウマチ薬としての合成

Author (9)： CHEN J J (Roche Biosci., CA, USA) ,  DEWDNEY N (Roche Biosci., CA, USA) ,  LIN X (Roche Biosci., CA, USA) ,  MARTIN R L (Roche Biosci., CA, USA) ,  WALKER K A M (Roche Biosci., CA, USA) ,  HUANG J (Roche Biosci., CA, USA) ,  SARMA K (Roche Biosci., CA, USA) ,  ARZENO H (Roche Biosci., CA, USA) ,  VAN WART H E (Roche Biosci., CA, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 13  Issue： 22  Page： 3951-3954  Publication year： Nov. 17, 2003 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *nitrogen heterocyclic compound ,...
Semi thesaurus term： rheumatoid arthritis

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JST classification (3)： Pyrazines  (CF07104N) ,  Structure-activity relationship of drugs  (GV01050B) ,  Basic research of anti-inflammatory drugs  (GW15010T)

Substance index (25)： (2R)-N-Hydroxy-1-(4-phenyl-1,2,3,6-tetrahydropyridine-1-ylsulfonyl)piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-bromophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-methoxyphenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-biphenylyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(3-biphenylyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-phenoxyphenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(3,4-difluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(3-ethylphenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-propylphenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperidine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]piperazine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-(dimethylcarbamoyl)piperazine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-(methylcarbamoyl)piperazine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-(morpholinocarbonyl)piperazine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-(dimethylsulfamoyl)piperazine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-[bis(dimethylamino)phosphinyl]piperazine-2β-carboxamide ,  (2R)-N-Hydroxy-1-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-(2,2,2-trifluoroethyl)piperazine-2β-carboxamide ,  1-Boc-Piperidine-4-one ,  1-(tert-Butoxycarbonyl)-4-(trifluoromethylsulfonyloxy)-1,2,3,6-tetrahydropyridine ,  1-(tert-Butoxycarbonyl)-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine ,  4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine-1-sulfonic acid chloride ,  Piperazine-2β-carboxylic acid ,  (2R)-1-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine-1-ylsulfonyl]-4-(dimethylcarbamoyl)piperazine-2β-carboxylic acid

Terms in the title (4)： 活性 ,  TNF阻害剤 ,  設計 ,  慢性関節リウマチ