Art

J-GLOBAL ID：200902261593363805   Reference number：07A0878715

Decreased Intestinal CYP3A and P-glycoprotein Activities in Rats with Adjuvant Arthritis

アジュバンド関節炎ラットにおける腸CYP3AとP-糖蛋白質活性の低下

Author (6)： UNO Satoshi (Dep. of Pharmacy, Kinki Univ.) ,  UNO Satoshi (Pharmaceutical Res., Pharmaceuticals R&D Div., Alfresa Pharma Corp.) ,  KAWASE Atsushi (Dep. of Pharmacy, Kinki Univ.) ,  TSUJI Akiko (Dep. of Pharmacy, Kinki Univ.) ,  TANINO Tadatoshi (Dep. of Pharmacy, Kinki Univ.) ,  IWAKI Masahiro (Dep. of Pharmacy, Kinki Univ.)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 22  Issue： 4  Page： 313-321 (J-STAGE)  Publication year： 2007 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： *rheumatoid arthritis ,...

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JST classification (3)： Gene expression  (EC02040Q) ,  Basic medicine on musculoskeletal system  (GG01020B) ,  Basic biopharmacy  (GY01021U)

Reference (45)：

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• SUKHAI, M. Regulation of the multidrug resistance genes by stress signals. J. Pharm. Pharm. Sci. 2000, 3, 268-280
• CHEN, Y. L. Effects of interleukin-6 on cytochrome P450-dependent mixed-function oxidases in the rat. Biochem. Pharmacol. 1992, 44, 137-148
• MORGAN, E. T. Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev. 1997, 29, 1129-1188
• SHEDLOFSKY, S. I. Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism. J. Clin. Invest. 1994, 94, 2209-2214

Terms in the title (7)： アジュバンド ,  関節 ,  ラット ,  腸 ,  CYP3A ,  P-糖蛋白質 ,  活性