Art

J-GLOBAL ID：200902261608880291   Reference number：04A0018590

EGFR tyrosine kinase inhibitor “gefitinib (Iressa)” for cancer therapy.

EGFRチロシンキナーゼ阻害薬ゲフィチニブ(イレッサ)と癌

Author (3)： YANO SEIICHI (アストラゼネカ 研究開発本部) ,  YAMAGUCHI MOTONORI (アストラゼネカ 研究開発本部) ,  DONG R-P (アストラゼネカ 研究開発本部)
Material： 日本薬理学雑誌  (日本薬理学会西南部会抄録)
Volume： 122  Issue： 6  Page： 491-497  Publication year： Dec. 01, 2003 
JST Material Number： G0740A  ISSN： 0015-5691  CODEN： NYKZA  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *tyrosine kinase ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (1)： Gefitinib

Reference (24)：

• 1) Downward J, Yarden Y, Mayes E, et al. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 1984;307:521-527.
• 2) Ullrich A, Coussens L, Hayflick JS, et al. Human epidermal growth factor receptor DNA sequence and aberrant expression of the amplified gene in A431 epidermal carcinoma cells. Nature. 1984;309:418-425.
• 3) Gullick WJ. Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers. Br Med Bull. 1991;47:87-98.
• 4) Fontanini G, Vignati S, Bigini D, et al. Epidermal growth factor receptor (EGFr) expression in non-small cell lung carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype. Eur J Cancer. 1995;31A:178-183.
• 5) Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol/Hematol. 1995;19:183-232.

Terms in the title (4)： EGFRチロシンキナーゼ阻害薬 ,  ゲフィチニブ ,  イレッサ ,  癌