Art

J-GLOBAL ID：200902263581896665   Reference number：04A0082056

P1 and P3 optimization of novel bicycloproline P2 bearing tetrapeptidyl α-ketoamide based HCV protease inhibitors

ビシクロプロリンP2部位を持つテトラペプチジルα-ケトアミドに基づく新規HCVプロテアーゼ阻害剤のP1及びP3部位最適化

Author (9)： VICTOR F (Eli Lilly and Co., IN, USA) ,  LAMAR J (Eli Lilly and Co., IN, USA) ,  SNYDER N (Eli Lilly and Co., IN, USA) ,  YIP Y (Eli Lilly and Co., IN, USA) ,  GUO D (Eli Lilly and Co., IN, USA) ,  YUMIBE N (Eli Lilly and Co., IN, USA) ,  JOHNSON R B (Eli Lilly and Co., IN, USA) ,  WANG Q M (Eli Lilly and Co., IN, USA) ,  CHEN S-H (Eli Lilly and Co., IN, USA)
Material： Bioorganic & Medicinal Chemistry Letters  (Bioorg Med Chem Lett)
Volume： 14  Issue： 1  Page： 257-261  Publication year： Jan. 05, 2004 
JST Material Number： W0248A  ISSN： 0960-894X  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *oligopeptide ,...

   To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=04A0082056&from=J-GLOBAL&jstjournalNo=W0248A") }}

JST classification (2)： Peptides  (CF10080G) ,  Synthesis of drugs  (GV01030F)

Substance index (18)： LY-514962 ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-(cyclopropylamino)ethyl]-3,3-difluoropropyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-[[(S)-sec-butyl]amino]ethyl]-3,3-difluoropropyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-[[(S)-α-methylbenzyl]amino]ethyl]-3,3-difluoropropyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  LY-526181 ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-[[(S)-sec-butyl]amino]ethyl]butyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-3-methyl-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-[[(S)-α-methylbenzyl]amino]ethyl]butyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-3-methyl-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-(cyclopropylamino)ethyl]-3,3-difluoropropyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-3-methyl-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  rac-(1S,3aβ,6aβ)-N-[(1R^*)-1-[1,2-Dioxo-2-[[(S)-sec-butyl]amino]ethyl]-3,3-difluoropropyl]-2-[N-(pyrazine-2-ylcarbonyl)-L-Val-3-methyl-L-Val-]octahydrocyclopenta[c]pyrrole-1β-carboxamide ,  LY-533549 ,  Z-Valine ,  3-Methyl-L-valine methyl ester ,  N-(Pyrazine-2-ylcarbonyl)-L-Val-3-methyl-L-Val-OH ,  rac-(3R^*)-2-Hydroxy-3-(benzyloxycarbonylamino)hexanoic acid ,  rac-(3R^*)-N-Cyclopropyl-2-hydroxy-3-aminohexanamide ,  rac-(2R^*)-2-(tert-Butoxycarbonylamino)-4,4-difluorobutanoic acid ,  rac-(3R^*)-N-[(S)-α-Methylbenzyl]-2-hydroxy-3-(trifluoroacetylamino)-5,5-difluoropentanamide ,  (3S)-3β,4β-Trimethylene-L-proline ethyl ester

Terms in the title (4)： ケトアミド ,  HCV ,  プロテアーゼ阻害剤 ,  最適化