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J-GLOBAL ID：200902263614819335   Reference number：08A0392809

Decreased Expression of Angiotensin II Type 1 and Type 2 Receptors in the Brain After Long-Term Administration of Antihypertensive Drugs in Stroke-Prone Spontaneously Hypertensive Rat

脳卒中易発症高血圧自然発症ラットにおける降圧剤長期投与後の脳におけるアンジオテンシンII1型および2型受容体の発現低下

Author (5)： NISHIDA Yayoi (Div. of Genomic Epidemiology and Clinical Trials, Nihon Univ. School of Medicine, JPN) ,  TAKAHASHI Yasuo (Div. of Genomic Epidemiology and Clinical Trials, Nihon Univ. School of Medicine, JPN) ,  SUGAHARA-KOBAYASHI Megumi (Dep. of Pharmacology, Nihon Univ. School of Medicine, JPN) ,  ISHIKAWA Kouichi (Dep. of Pharmacology, Nihon Univ. School of Medicine, JPN) ,  ASAI Satoshi (Div. of Genomic Epidemiology and Clinical Trials, Nihon Univ. School of Medicine, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 106  Issue： 4  Page： 663-666 (J-STAGE)  Publication year： 2008 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *cerebral apoplexy ,...
Semi thesaurus term： Angiotensin III

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic neurology  (GN01020W)

Substance index (3)： Valsartan ,  Enalapril ,  Amlodipine

Reference (15)：

• DE GASPARO, M. International union of pharmacology. XXIII The angiotensin II receptors. Pharmacol Rev. 2000, 52, 415-472
• SIRAGY, HM. The role of the AT2 receptor in hypertension. Am J Hypertens. 2000, 13, 62S-67S
• VON BOHLEN UND HALBACH, O. The CNS renin-angiotensin system. Cell Tissue Res. 2006, 326, 599-616
• ANDO, H. Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain. Ann N Y Acad Sci. 2004, 1018, 345-350
• MCKINLEY, MJ. Physiological actions of angiotensin II mediated by AT1 and AT2 receptors in the brain. Clin Exp Pharmacol Physiol Suppl. 1996, 3, S99-S104

Terms in the title (6)： 脳卒中易発症高血圧自然発症ラット ,  降圧剤 ,  長期投与 ,  脳 ,  受容体 ,  発現