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J-GLOBAL ID：200902264986113362   Reference number：08A0630164

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer

膵臓癌において,低酸素での肝増殖因子アクチベーター遺伝子発現の誘導は,低酸素誘導因子1を経て肝増殖因子/c-Metシステムを活性化する

Author (4)： KITAJIMA Yoshihiko (Saga Univ. Fac. of Medicine, Saga, JPN) ,  IDE Takao (Saga Univ. Fac. of Medicine, Saga, JPN) ,  OHTSUKA Takao (Saga Univ. Fac. of Medicine, Saga, JPN) ,  MIYAZAKI Kohji (Saga Univ. Fac. of Medicine, Saga, JPN)
Material： Cancer Science  (Cancer Sci)
Volume： 99  Issue： 7  Page： 1341-1347  Publication year： Jul. 2008 
JST Material Number： W1423A  ISSN： 1347-9032  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *pancreatic tumor ,...
Semi thesaurus term： *HGFA ,...

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JST classification (3)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Biological function  (EB03040U)

Reference (30)：

• NAKAMURA, T. Molecular cloning and expression of human hepatocyte growth factor. Nature. 1989, 342, 440-443
• MONTESANO, R. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell. 1991, 67, 901-908
• MATSUMOTO, K. Emerging multipotent aspects of hepatocyte growth factor. J Biochem. 1996, 119, 591-600
• GAK, E. Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity. FEBS Lett. 1992, 311, 17-21
• MIYAZAWA, K. Activation of hepatocyte growth factor in the injured tissues is mediated by hepatocyte growth factor activator. J Biol Chem. 1996, 271, 3615-3618

Terms in the title (9)： 膵臓癌 ,  低酸素 ,  肝増殖因子アクチベーター ,  遺伝子発現 ,  誘導 ,  低酸素誘導因子1 ,  増殖因子 ,  c-met ,  活性化