Art

J-GLOBAL ID：200902265010918672   Reference number：08A0285887

Phenoxazine Derivatives Inactivate Human Cytomegalovirus, Herpes Simplex Virus-1, and Herpes Simplex Virus-2 In Vitro

フェノキサジン誘導体はヒトサイトメガロウイルス,単純ヘルペスウイルス-1,及び単純ヘルペスウイルス-2をin vitroで不活性化する

Author (3)： HAYASHI Kyoko (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama, JPN) ,  HAYASHI Toshimitsu (Graduate School of Medicine and Pharmaceutical Sciences, Univ. of Toyama, JPN) ,  TOMODA Akio (Dep. of Biochemistry, and Intractable Immune System Disease Res. Center, Tokyo Medical Univ., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 106  Issue： 3  Page： 369-375 (J-STAGE)  Publication year： 2008 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Simplexvirus ,...
Semi thesaurus term： herpes simplex virus 1 ,...

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JST classification (3)： Basic research of antiviral drugs  (GW17040O) ,  Nitrogen heterocycles in general  (CF07040G) ,  Oxygen heterocycles in general  (CF07020K)

Substance index (4)： Questiomycin A ,  2-Amino-4α,7-dimethyl-4,4aα-dihydro-3H-phenoxazine-3-one ,  3-Amino-4α,8-dimethyl-1,4aα-dihydro-2H-phenoxazine-2-one ,  Ganciclovir

Reference (29)：

• 1 Sinzger C, Jahan G. Human cytomegalovirus cell tropism and pathogenesis. Intervirolgy. 1996;39:302–319.
• 2 Weller TH. The cytomegaloviruses: uniquitous agents with protean clinical manifestations. II. N Engl J Med. 1971;285:267–274.
• 3 Odeberg J, Wolmer N, Westgren M, Seiger A, Soderberg-Naucler C. Human cytomegalovirus inhibits neuronal differentiation and induces apoptosis in human neural precursor cells. J Virol. 2006;80:8929–8939.
• 4 Elion G. Mechanism of action of antiviral selectivity of acyclovir. Am J Med. 1982;73:7–13.
• 5 Faulds D, Heal RC. Gansiclovir. A review of the antiviral activity, pharmacolinetic properties and therapeutic efficacy in cytomegalovirus infections. Drugs. 1990;39:597–638.

Terms in the title (4)： フェノキサジン誘導体 ,  ヒトサイトメガロウイルス ,  単純ヘルペスウイルス ,  不活性化