Art

J-GLOBAL ID：200902265745635984   Reference number：08A0236007

HMG-CoA Reductase Inhibitor, Simvastatin Improves Reverse Cholesterol Transport in Type 2 Diabetic Patients with Hyperlipidemia

高脂血症を伴う2型糖尿病患者においてHMG-CoAレダクターゼ阻害剤,シンバスタチンはコレステロール逆輸送を改善する

Author (8)： GUAN Jing-zhi (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  TAMASAWA Naoki (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  MURAKAMI Hiroshi (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  MATSUI Jun (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  TANABE Jutaro (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  MATSUKI Kota (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  YAMASHITA Maki (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.) ,  SUDA Toshihiro (Dep. of Endocrinology and Metabolism, Hirosaki Univ. Graduate School of Medicine.)
Material： Journal of Atherosclerosis and Thrombosis  (J Atheroscler Thromb)
Volume： 15  Issue： 1  Page： 20-25 (J-STAGE)  Publication year： 2008 
JST Material Number： L2187A  ISSN： 1340-3478  CODEN： JATHEH  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *non-insulin-dependent diabetes mellitus ,...

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JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Clinical application of drugs acting on lipid metabolism  (GW13050X)

Substance index (1)： Simvastatin

Reference (30)：

• 1) Krauss RM: Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care, 2004; 27: 1496-1504
• 2) Martin G, Duez H, Blanquart C, Berezowski V, Poulain P, Fruchart JC, Najib-Fruchart J, Glineur C, and Staels B: Statin-induced inhibition of the Rho-signaling pathway activates PPAR α and induces HDL ApoA-I. J Clin Invest, 2001; 107: 1423-1432
• 3) Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian simvastatin survival study (4S): Lancet, 1994; 344: 1383-1389
• 4) Forcheron F, Cachefo A, Thevenon S, Pinteur C, and Beylot M: Mechanisms of the triglyceride- and cholesterol-lowering effect of fenofibrate in hyperlipidemic type 2 diabetic patients. Diabetes, 2002; 51: 3486-3491
• 5) Shepherd J: Does statin monotherapy address the multiple lipid abnormalities in type 2 diabetes? Atheroscler Suppl, 2005; 6: 15-19

Terms in the title (6)： 高脂血症 ,  2型糖尿病 ,  患者 ,  HMG-CoAレダクターゼ阻害剤 ,  シンバスタチン ,  コレステロール逆輸送