Art

J-GLOBAL ID：200902265844053350   Reference number：05A0382013

Establishment of a Bioassay System for Detection of Lung Toxicity Due to Fine Particle Instillation: Sequential Histopathological Changes with Acute and Subacute Lung Damage Due to Intratracheal Instillation of Quartz in F344 Male Rats

細かい粒子吸入による肺毒性の検出に対するバイオアッセイ系の確立 F344雄ラットにおける水晶の経気管点滴注入による急性と亜急性肺傷害を伴う連続した病理組織学的変化

Author (12)： YOKOHIRA Masanao (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  YOKOHIRA Masanao (1st Dep. of Surgery, Fac. of Medicine, Kagawa Univ.) ,  TAKEUCHI Hijiri (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  TAKEUCHI Hijiri (1st Dep. of Surgery, Fac. of Medicine, Kagawa Univ.) ,  YAMAKAWA Keiko (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  SAO Kousuke (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  IKEDA Mico (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  MATSUDA Yoko (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  ZENG Yu (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  HOSOKAWA Kyoko (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.) ,  MAETA Hajime (1st Dep. of Surgery, Fac. of Medicine, Kagawa Univ.) ,  IMAIDA Katsumi (Onco-Pathology, Dep. of Pathology and Host-Defense, Kagawa Medical Univ.)
Material： Journal of Toxicologic Pathology  (J Toxicol Pathol)
Volume： 18  Issue： 1  Page： 13-18 (J-STAGE)  Publication year： 2005 
JST Material Number： L1510A  ISSN： 0914-9198  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *fine particle ,...
Semi thesaurus term： pneumotoxicity ,...

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JST classification (1)： Toxicity of inorganic compounds in general  (GZ02021E)

Substance index (1)： Bromodeoxyuridine

Reference (18)：

• 1. Ghio AJ and Huang YC. Exposure to concentrated ambient particles (CAPs): a review. Inhal Toxicol. 16: 53-59. 2004.
• 2. Tjoe-Nij E, Meer Gd G, Smit J, and Heederik D. Lung function decrease in relation to pneumoconiosis and exposure to quartz-containing dust in construction workers. Am J Ind Med. 43: 574-583. 2003.
• 3. Repine JE, Bast A, Lankhorst I, and The Oxidative Stress Study Group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 156: 341-357. 1997.
• 4. Linden M, Rasmussen JB, Piitulainen E, Tunek A, Larson M, Tegner H, Venge P, Laitinen LA, and Brattsand R. Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis. Am Rev Respir Dis. 148: 1226-1232. 1993.
• 5. Bowden DH and Adamson IY. The role of cell injury and the continuing inflammatory response in the generation of silicotic pulmonary fibrosis. J Pathol. 144: 149-161. 1984.

Terms in the title (10)： 吸入 ,  肺毒性 ,  バイオアッセイ ,  雄 ,  ラット ,  水晶 ,  気管 ,  点滴注入 ,  急性肺傷害 ,  病理組織学