Art

J-GLOBAL ID：200902266129211662   Reference number：04A0394471

Factors Affecting Glucuronidation Activity in Caco-2 Cells

Caco-2細胞におけるグルクロニル化活性に影響する因子

Author (4)： MIZUMA T (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN) ,  MOMOTA R (Sci. Univ. Tokyo, Chiba, JPN) ,  HAGA M (Sci. Univ. Tokyo, Chiba, JPN) ,  HAYASHI M (Tokyo Univ. Pharmacy and Life Sci., Tokyo, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 19  Issue： 2  Page： 130-134  Publication year： Apr. 26, 2004 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： oral administration ,...
Semi thesaurus term： glucuronide

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JST classification (1)： Basic biopharmacy  (GY01021U)

Substance index (1)： 1-Naphthol

Reference (14)：

• 1) Rowland, M. and Tozer, T. N.: Clinical Pharmacokinetics. Concepts and Applications. Philadelphia, Williams & Wilkins, 1995, pp. 119.
• 2) Mizuma, T.: Kinetic impact of presystemic intestinal metabolism on drug absorption: experiment and data analysis for the prediction of in vivo absorption from in vitro data. Drug Metabol. Pharmacokin. 17: 496-506 (2002).
• 3) Klippert, P., Borm, P. and Noordhoek, J.: Prediction of intestinal first-pass effect of phenacetin in the rat from enzyme kinetic data-correlation with in vivo data using mucosal blood flow. Biochem. Pharmacol., 31: 2545-2548 (1982).
• 4) Borm, P. J. A., Frankhuyzen-Sierevogel, A. C., Weller, E. B. C. and Noordhoek, J.: Absorption and metabolism of hexamethylmelamine and pentamethylmelamine in rat everted perfused gut segments: correlation with in vitro data. J. Pharm. Pharmacol., 37: 629-636 (1985).
• 5) Thummel, K. E., Kunze, K. L. and Shen, D. D.: Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction. Adv. Drug Delivery Rev., 27: 99-127 (1997).

Terms in the title (4)： Caco-2細胞 ,  グルクロニル化 ,  活性 ,  因子