Art

J-GLOBAL ID：200902266561983714   Reference number：09A0630064

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

RIP1-RIP3複合体のリン酸化駆動アセンブリーはプログラム壊死およびウイルス誘導性炎症を調節する

Author (14)： CHO Youngsik (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  CHO Youngsik (Immunology and Virology Program, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  CHO Youngsik (Center for Metabolic Syndrome Therapeutics, Bio-Organic Sci. Div., Korea Res. Inst. of Chemical Technol., Yuseong-gu ...) ,  CHALLA Sreerupa (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  CHALLA Sreerupa (Immunology and Virology Program, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  MOQUIN David (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  MOQUIN David (Immunology and Virology Program, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  GENGA Ryan (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  RAY Tathagat Dutta (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  RAY Tathagat Dutta (Immunology and Virology Program, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  GUILDFORD Melissa (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  CHAN Francis Ka-Ming (Dep. of Pathology, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  CHAN Francis Ka-Ming (Immunology and Virology Program, Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA) ,  CHAN Francis Ka-Ming (Center for AIDS Res., Univ. of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 137  Issue： 6  Page： 1112-1123  Publication year： Jun. 12, 2009 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： protein complex ,  *Cell Death ,  knockout mouse ,  adaptor protein ,  *serine-threonine kinase ,  Enzyme Activation ,  RNA interference ,  genetic technique ,  Vaccinia virus ,  viral infection ,  active oxygen ,  Inflammation ,  NF-kappaB ,  Transfection ,  fibroblast ,  cultured cell ,  Western blotting ,  TNF ,  Jurkat cell ,  caspase ,  flow cytometry ,  concentration dependence ,  phosphorylation ,  electron microscopy ,  SDS-PAGE ,  quinone ,  alicyclic compound ,  macrocyclic compound ,  lactam ,  diene ,  carbamate ,  enol ether ,  diol ,  acid imide ,  alicyclic ketone ,  secondary alcohol ,  hydroxy ketone ,  T cell ,  L929 cell ,  MEF cell ,  Caspase 8 ,  programmed cell death ,  Inflammation reaction ,  immune response ,  RIPK1 ,  RIPK3 ,  laboratory animal ,  Mus musculus ,  Heredity ,  microorganism ,  Poxviridae ,  bioassay
Semi thesaurus term： immunological reaction ,  T lymphocyte ,  RIP1 ,  RIP3 ,  genetic screening ,  *細胞壊死

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (5)： DCFH-DA ,  z-VAD-fmk ,  Geldanamycin ,  Cycloheximide ,  Nec-1

Terms in the title (9)： RIP1 ,  RIP3 ,  複合体 ,  リン酸化 ,  アセンブリー ,  壊死 ,  ウイルス ,  炎症 ,  調節