Art

J-GLOBAL ID：200902267901319357   Reference number：09A0773189

HPLC analysis of lipoproteins in culture medium of hepatoma cells: an in vitro system for screening antihyperlipidemic drugs

肝癌細胞の培養培地におけるリポ蛋白質のHPLC解析:抗高脂血症薬のスクリーニングに対するin vitro系

Author (11)： ITOH Mizuho (Skylight Biotech Inc., Akita, JPN) ,  ABE Yukie (Skylight Biotech Inc., Akita, JPN) ,  IWAMA Yuka (Skylight Biotech Inc., Akita, JPN) ,  KIMURA Fumiko (Skylight Biotech Inc., Akita, JPN) ,  SATOH Mayumi (Skylight Biotech Inc., Akita, JPN) ,  SHOJI Mayumi (Skylight Biotech Inc., Akita, JPN) ,  TAKAHASHI Junichiro (Skylight Biotech Inc., Akita, JPN) ,  TOSHIMA Gen (Skylight Biotech Inc., Akita, JPN) ,  SASAKI Hiroki (Skylight Biotech Inc., Akita, JPN) ,  HIWATASHI Kazuyuki (Akita Prefectural Agricultural, Forestry, and Fisheries Res. Center, Akita, JPN) ,  HATA Keishi (Akita Prefectural Agricultural, Forestry, and Fisheries Res. Center, Akita, JPN)
Material： Biotechnology Letters  (Biotechnol Lett)
Volume： 31  Issue： 7  Page： 953-957  Publication year： Jul. 2009 
JST Material Number： E0971A  ISSN： 0141-5492  CODEN： BILED3  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： tumor cell ,  hyperlipidemia ,  medium(culture) ,  *lipoprotein ,  high performance liquid chromatography ,  *hypolipidemic drug ,  screening(inspection) ,  in vitro experiment ,  secretion(physiology) ,  HepG2 cell ,  triglyceride ,  RT-PCR ,  transcription factor ,  DNA binding protein ,  apo B ,  apo A-I ,  gene ,  gene expression ,  *cultured cell ,  sterol ,  alicyclic alcohol ,  alicyclic compound ,  lactone ,  aliphatic carboxylic acid ,  conjugated diene ,  aromatic ketone ,  aromatic chlorine compound ,  phenol ether ,  carboxylate(ester) ,  enzyme inhibitor ,  HMG-CoA reductase inhibitor
Semi thesaurus term： HPLC analysis ,  Apolipoprotein B-100 ,  sterol regulatory element binding protein-1c ,  sterol regulatory element binding protein-2 ,  real time RT-PCR method ,  hepatoma cell ,  hypolipidemic drug ,  culture medium

JST classification (3)： Basic research of drugs acting on lipid metabolism  (GW13040M) ,  Cell and tissue culture methods  (EA03040R) ,  Biochemistry of lipids in general  (EB05010B)

Substance index (3)： Cholesterol ,  Simvastatin ,  Fenofibrate

Terms in the title (7)： 肝癌細胞 ,  培養培地 ,  リポ蛋白質 ,  HPLC ,  解析 ,  抗高脂血症薬 ,  スクリーニング