Art

J-GLOBAL ID：200902268070854575   Reference number：08A0171988

GHRP-2, a GHS-R agonist, directly acts on myocytes to attenuate the dexamethasone-induced expressions of muscle-specific ubiquitin ligases, Atrogin-1 and MuRF1

GHS-R 作用薬GHRP-2は,筋肉細胞に直接作用し,デキサメタゾン誘発の筋肉特異的ユビキチンリガーゼ, Atrogin-1及びMuRF1の発現を減弱する

Author (11)： YAMAMOTO Daisuke (Dep. of Basic Allied Medicine, Kobe Univ. School of Medicine, Kobe, JPN) ,  IKESHITA Nobuko (Dep. of Basic Allied Medicine, Kobe Univ. School of Medicine, Kobe, JPN) ,  MATSUBARA Takako (Dep. of Physical Therapy, Kobe Univ. School of Medicine, Kobe, JPN) ,  TASAKI Hiromitsu (Dep. of Physical Therapy, Kobe Univ. School of Medicine, Kobe, JPN) ,  HERNINGTYAS Elizabeth Henny (Div. of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Dep. of Clinical Molecular Medicine, Kobe Univ. ...) ,  TODA Keizo (Dep. of Basic Allied Medicine, Kobe Univ. School of Medicine, Kobe, JPN) ,  IIDA Keiji (Div. of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Dep. of Clinical Molecular Medicine, Kobe Univ. ...) ,  TAKAHASHI Yutaka (Div. of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Dep. of Clinical Molecular Medicine, Kobe Univ. ...) ,  KAJI Hidesuke (Coll. of Nursing Art and Sci., Univ. of Hyogo, Akashi, JPN) ,  CHIHARA Kazuo (Div. of Endocrinology/Metabolism, Neurology and Hematology/Oncology, Dep. of Clinical Molecular Medicine, Kobe Univ. ...) ,  OKIMURA Yasuhiko (Dep. of Basic Allied Medicine, Kobe Univ. School of Medicine, Kobe, JPN)
Material： Life Sciences  (Life Sciences including Pharmacology Letters)
Volume： 82  Issue： 9-10  Page： 460-466  Publication year： Feb. 27, 2008 
JST Material Number： B0699B  ISSN： 0024-3205  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： protein ,  *myocyte ,  muscle ,  ubiquitin-activating enzyme ,  muscular atrophy ,  rat ,  soleus muscle ,  mRNA ,  plasma concentration ,  IGF1 ,  steroid ,  diene ,  organofluorine compound ,  enone ,  alicyclic alcohol ,  alicyclic ketone ,  diketone ,  secondary alcohol ,  hydroxy ketone ,  polyol ,  steroid hormone ,  glucocorticoid
Semi thesaurus term： GHS

JST classification (1)： Basic medicine on musculoskeletal system  (GG01020B)

Substance index (2)： KP-102 ,  Dexamethasone

Terms in the title (9)： 作用薬 ,  筋肉細胞 ,  デキサメタゾン ,  誘発 ,  筋肉 ,  ユビキチンリガーゼ ,  MuRF1 ,  発現 ,  減弱