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J-GLOBAL ID：200902268258605998   Reference number：08A0735973

Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

長期モルヒネ処置はセリンラセマーゼおよびD-アミノ酸酸化酵素のmRNAおよびタンパク質発現を介してラット脳でのD-セリン含有量を増大する

Author (8)： YOSHIKAWA Masanobu (Dep. of Clinical Pharmacology, Tokai Univ. School of Medicine, JPN) ,  SHINOMIYA Takashi (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  TAKAYASU Naoko (Lab. for Molecular Sci. Res., Tokai Univ. School of Medicine, JPN) ,  TSUKAMOTO Hideo (Lab. for Molecular Sci. Res., Tokai Univ. School of Medicine, JPN) ,  KAWAGUCHI Mitsuru (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  KOBAYASHI Hiroyuki (Dep. of Clinical Pharmacology, Tokai Univ. School of Medicine, JPN) ,  OKA Tetsuo (Dep. of Clinical Pharmacology, Tokai Univ. School of Medicine, JPN) ,  HASHIMOTO Atsushi (Dep. of Clinical Pharmacology, Tokai Univ. School of Medicine, JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 107  Issue： 3  Page： 270-276 (J-STAGE)  Publication year： 2008 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： NMDA receptor ,...

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JST classification (2)： Basic neurology  (GN01020W) ,  Basic research of addictive analgesics and narcotics  (GW03080Z)

Substance index (2)： D-Serine ,  Morphine

Reference (38)：

• HASHIMOTO, A. Endogenous D-serine in rat brain : N-methyl-D-aspartate receptor-related distribution and aging. J Neurochem. 1993, 60, 783-786
• SCHELL, MJ. D-serine, an endogenous synaptic modulator : localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci USA. 1995, 92, 3948-3952
• HASHIMOTO, A. Free D-aspartate and D-serine in the mammalian brain and periphery. Prog Neurobiol. 1997, 52, 325-353
• HASHIMOTO, A. Extracellular concentration of endogenous free D-serine in the rat brain as revealed by in vivo microdialysis. Neuroscience. 1995, 66, 635-643
• WOLOSKER, H. Serine racemase : a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci USA. 1999, 96, 13409-13414

Terms in the title (13)： 長期 ,  モルヒネ ,  処置 ,  セリンラセマーゼ ,  D-アミノ酸 ,  酸化酵素 ,  mRNA ,  タンパク質 ,  発現 ,  ラット ,  脳 ,  D-セリン ,  含有量