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J-GLOBAL ID：200902268617286399   Reference number：04A0564506

Antibody Reactive to a Hepatitis C Virus (HCV)-Derived Peptide Capable of Inducing HLA-A2 Restricted Cytotoxic T Lymphocytes Is Detectable in a Majority of HCV-Infected Individuals without HLA-A2 Restriction

HLA-A2拘束性細胞傷害性Tリンパ球を誘導可能なC型肝炎ウイルス(HCV)由来ペプチドに反応する抗体はHLA-A2拘束性なしにHCV感染者の大部分に検出できる

Author (5)： TAKAO Y (Kurume Univ. School of Medicine, Fukuoka, JPN) ,  YAMADA A (Kurume Univ., Kurume, Fukuoka, JPN) ,  YUTANI S (Kurume Univ. School of Medicine, Fukuoka, JPN) ,  SATA M (Kurume Univ. Res. Center for Innovative Cancer Therapy, Fukuoka, JPN) ,  ITOH K (Kurume Univ. School of Medicine, Fukuoka, JPN)
Material： Microbiology and Immunology  (Microbiol Immunol)
Volume： 48  Issue： 7  Page： 507-517  Publication year： Jul. 20, 2004 
JST Material Number： F0715A  ISSN： 0385-5600  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *immunoglobulin G ,...
Semi thesaurus term： core protein ,...

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JST classification (2)： Infectious diseases,parasitics diseases in general.  (GD01010H) ,  Antigens,antibodies,complements in general  (ED04010A)

Reference (25)：

• ALEXANDER, J. Recognition of a novel naturally processed, A2 restricted, HCV-NS4 epitope triggers IFN-gamma release in absence of detectable cytopathicity. Hum. Immunol. 1998, 59, 776-782
• AKATSUKA, T. B cell epitopes on the hepatitis C virus nucleocapsid protein determined by human monospecific antibodies. Hepatology. 1993, 18, 503-510
• BATTEGAY, M. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J. Virol. 1995, 69, 2462-2470
• CAI, Q. Variant analysis and immunogenicity prediction of envelope gene of HCV strains from China. J. Med. Virol. 2002, 67, 490-500
• CERINO, A. A human monoclonal antibody specific for the N-terminus of the hepatitis-C virus nucleocapsid protein. J. Immunol. 1993, 151, 7005-7015

Terms in the title (9)： HLA-A2 ,  拘束 ,  細胞傷害性Tリンパ球 ,  誘導 ,  C型肝炎ウイルス ,  HCV ,  ペプチド ,  抗体 ,  HCV感染