Art

J-GLOBAL ID：200902268743399344   Reference number：07A0934430

Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice

記憶を改善する柑橘類フラボノイド,ノビレチンはマウスにおける嗅球摘除誘導コリン作動性神経変性を救済する

Author (14)： NAKAJIMA Akira (Dep. of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  YAMAKUNI Tohru (Dep. of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  HARAGUCHI Mitsuya (Dep. of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  OMAE Naoki (Dep. of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  SONG Si-young (Inst. of Neuroscience, Tokushima Bunri Univ. at Kagawa, JPN) ,  KATO Chieko (Inst. of Neuroscience, Tokushima Bunri Univ. at Kagawa, JPN) ,  NAKAGAWASAI Osamu (Dep. of Pharmacology, Tohoku Pharmaceutical Univ., JPN) ,  TADANO Takeshi (Dep. of Pharmacology, Tohoku Pharmaceutical Univ., JPN) ,  YOKOSUKA Akihito (Lab. of Medicinal Plant Sci., School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci., JPN) ,  MIMAKI Yoshihiro (Lab. of Medicinal Plant Sci., School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci., JPN) ,  SASHIDA Yutaka (Lab. of Medicinal Plant Sci., School of Pharmacy, Tokyo Univ. of Pharmacy and Life Sci., JPN) ,  OHIZUMI Yasushi (Dep. of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku Univ., JPN) ,  OHIZUMI Yasushi (Yokohama Coll. of Pharmacy, JPN) ,  OHIZUMI Yasushi (Res. Center of Supercritical Fluid Technol., Graduate School of Engineering, Tohoku Univ., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 105  Issue： 1  Page： 122-126 (J-STAGE)  Publication year： 2007 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Mus musculus ,...
Semi thesaurus term： choline acetyltransferase

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JST classification (2)： Basic research of pharmacology of crude drugs  (GX06020J) ,  Basic neurology  (GN01020W)

Substance index (1)： Nobiletin

Reference (15)：

• BARTUS, RT. On neurodegenerative diseases, models, and treatment strategies : lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp Neurol. 2000, 163, 495-529
• SONG, C. The olfactory bulbectomised rat as a model of depression. Neurosci Biobehav Rev. 2005, 29, 627-647
• YAMAMOTO, T. Characteristics of memory dysfunction in olfactory bulbectomized rats and the effects of cholinergic drugs. Behav Brain Res. 1997, 83, 57-62
• HOZUMI, S. Characteristics of changes in cholinergic function and impairment of learning and memory-related behavior induced by olfactory bulbectomy. Behav Brain Res. 2003, 138, 9-15
• YOSHIMURA, H. Changes in acetylcholine content in rat brain after bilateral olfactory bulbectomy in relation to mouse-killing behavior. Pharmacol Biochem Behav. 1974, 2, 703-705

Terms in the title (7)： 柑橘類 ,  フラボノイド ,  ノビレチン ,  マウス ,  嗅球摘除 ,  誘導 ,  神経変性