Art

J-GLOBAL ID：200902268943448501   Reference number：04A0890233

IL-10 Augments Antibody Production in in Vitro Immunized Lymphocytes by Inducing a Th2-Type Response and B Cell Maturation

IL-10はTh2タイプの応答およびB細胞の成熟を誘導することによりin vitro免疫のリンパ球における抗体生産を増大させる

Author (9)： XU Q (Kyushu Univ., Fukuoka, JPN) ,  KATAKURA Y (Kyushu Univ., Fukuoka, JPN) ,  YAMASHITA M (Kyushu Univ., Fukuoka, JPN) ,  FANG S (Zhejiang Univ., Zhejiang, CHN) ,  TAMURA T (Kyushu Univ., Fukuoka, JPN) ,  MATSUMOTO S (Kyushu Univ., Fukuoka, JPN) ,  AIBA Y (Kyushu Univ., Fukuoka, JPN) ,  TERUYA K (Kyushu Univ., Fukuoka, JPN) ,  OSADA K (Kyushu Univ., Fukuoka, JPN)
Material： Bioscience, Biotechnology, and Biochemistry  (Bioscience Biotechnology & Biochemistry)
Volume： 68  Issue： 11  Page： 2279-2284  Publication year： Nov. 23, 2004 
JST Material Number： G0021A  ISSN： 0916-8451  CODEN： BBBIEJ  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *interleukin 10 ,...
Semi thesaurus term： B lymphocyte ,...

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JST classification (1)： Immunological reaction in general  (ED03010T)

Reference (9)：

• 1) James, K., and Bell, G. T., Human monoclonal antibody production. Current status and future prospects. J. Immunol. Methods, 100, 5–40 (1987).
• 2) Ichikawa, A., Katakura, Y., Hashizume, S., and Shirahata, S., In vitro immunization of human peripheral blood lymphocytes: establishment of B cell lines secreting IgM specific for cholera toxin B subunit from lymphocytes stimulated with IL-2 and IL-4. Cytotechnol., 31, 131–139 (1999).
• 3) Choe, J., and Choi, Y. S., IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells. Eur. J. Immunol., 28, 508–515 (1998).
• 4) Kindler, V., and Zubler, R. H., Memory, but not naïve, peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and co-stimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3. J. Immunol., 159, 2085–2090 (1997).
• 5) Kobayashi, N., Nagumo, H., and Agematsu, K., IL-10 enhances B-cell IgE synthesis by promoting differentiation into plasma cells, a process that is inhibited by CD27/CD70 interaction. Clin. Exp. Immunol., 129, 446–452 (2002).

Terms in the title (10)： IL-10 ,  Th2 ,  タイプ ,  応答 ,  B細胞 ,  成熟 ,  誘導 ,  免疫 ,  リンパ球 ,  抗体生産