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J-GLOBAL ID：200902269090932560   Reference number：07A0844550

Identification of Radicals Formed in the Reaction Mixtures of Rat Liver Microsomes with ADP, Fe³⁺ and NADPH Using HPLC-EPR and HPLC-EPR-MS

HPLC-EPR及びHPLC-EPR-MSを用いたADP,Fe³⁺及びNADPHとラット肝臓ミクロソームの反応混合物において形成されたラジカルの同定

Author (4)： MINAKATA Katsuyuki (Wakayama Medical Univ., Wakayama, JPN) ,  OKUNO Etsuo (Kyusyu Nutrition Welfare Univ., Fukuoka, JPN) ,  NAKAMURA Masayuki (Wakayama Medical Univ., Wakayama, JPN) ,  IWAHASHI Hideo (Wakayama Medical Univ., Wakayama, JPN)
Material： Journal of Biochemistry  (J Biochem)
Volume： 142  Issue： 1  Page： 73-78  Publication year： Jul. 01, 2007 
JST Material Number： F0286A  ISSN： 0021-924X  CODEN： JOBIAO  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： liver ,...
Semi thesaurus term： HPLC-EPR ,...

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JST classification (1)： Miscellaneous analytical methods of radicals in organic substances  (CC08033S)

Substance index (7)： POBN ,  ADP ,  EDTA ,  NADPH ,  Ethyl radical ,  Citric acid ,  (1-Hydroxypentyl)radical

Reference (18)：

• RASHBA-STEP, J. Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment. Arch. Biochem. Biophys. 1993, 300, 401-408
• STOYANOVSKY, D. A. ESR and HPLC-EC analysis of ethanol oxidation to 1-hydroxyethyl radical : rapid reduction and quantification of POBN and PBN nitroxides. Free Radic. Biol. Med. 1998, 25, 536-545
• ALBANO, E. Role of ethanol-inducible cytochrome P450 (P450IIE1) in catalysing the free radical activation of aliphatic alcohols. Biochem. Pharmacol. 1991, 41, 1895-1902
• CONNOR, H. D. Clarification of the relationship between free radical spin trapping and carbon tetrachloride metabolism in microsomal systems. Free Radic. Biol. Med. 1998, 24, 1364-1368
• RASHBA-STEP, J. Oxidation of glycerol to formaldehyde by microsomes : Are glycerol radicals produced in the reaction pathway?. Biochemistry. 1994, 33, 9504-9510

Terms in the title (9)： HPLC ,  EPR ,  ADP ,  NADPH ,  ラット ,  肝臓ミクロソーム ,  反応混合物 ,  ラジカル ,  同定