Art

J-GLOBAL ID：200902269857245351   Reference number：09A1024898

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

タンキラーゼの阻害はアキシンを安定化し,Wntシグナル伝達を阻害する

Author (36)： HUANG Shih-Min A. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  MISHINA Yuji M. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  LIU Shanming (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  CHEUNG Atwood (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  STEGMEIER Frank (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  MICHAUD Gregory A. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  CHARLAT Olga (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  WIELLETTE Elizabeth (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  ZHANG Yue (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  WIESSNER Stephanie (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  HILD Marc (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  SHI Xiaoying (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  WILSON Christopher J. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  MICKANIN Craig (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  MYER Vic (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  FAZAL Aleem (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  TOMLINSON Ronald (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  SERLUCA Fabrizio (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  SHAO Wenlin (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  CHENG Hong (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  SHULTZ Michael (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  RAU Christina (Cellzome AG, Heidelberg, DEU) ,  SCHIRLE Markus (Cellzome AG, Heidelberg, DEU) ,  SCHLEGL Judith (Cellzome AG, Heidelberg, DEU) ,  GHIDELLI Sonja (Cellzome AG, Heidelberg, DEU) ,  FAWELL Stephen (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  LU Chris (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  CURTIS Daniel (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  KIRSCHNER Marc W. (Harvard Medical School, Massachusetts, USA) ,  LENGAUER Christoph (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  FINAN Peter M. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  TALLARICO John A. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  BOUWMEESTER Tewis (Cellzome AG, Heidelberg, DEU) ,  PORTER Jeffery A. (Novartis Inst. for Biomedical Res., Massachusetts, USA) ,  BAUER Andreas (Cellzome AG, Heidelberg, DEU) ,  CONG Feng (Novartis Inst. for Biomedical Res., Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 461  Issue： 7264  Page： 614-620  Publication year： Oct. 01, 2009 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *ADP ribosyltransferase ,  enzyme inhibition ,  *enzyme inhibitor ,  ubiquitin ,  proteasome ,  proteolysis ,  catenin ,  transcription factor ,  beta Catenin ,  Axin ,  *Tankyrases ,  Signal Transduction ,  Wnt Signaling Pathway ,  Proteins
Semi thesaurus term： cellular signal transduction ,  Wnt signaling

JST classification (1)： Cell physiology in general  (EF02010S)

Substance index (1)： XAV-939

Terms in the title (5)： タンキラーゼ ,  阻害 ,  アキシン ,  安定化 ,  Wntシグナル伝達