Art

J-GLOBAL ID：200902270481938723   Reference number：09A0347615

Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity

SBMA神経毒性におけるアンドロゲン受容体のポリグルタミン伸張による異常E2F活性化

Author (26)： SUZUKI Eriko (Univ. Tokyo, Tokyo, JPN) ,  SUZUKI Eriko (JST-ERATO, Saitama, JPN) ,  ZHAO Yue (Univ. Tokyo, Tokyo, JPN) ,  ZHAO Yue (JST-ERATO, Saitama, JPN) ,  SAWATSUBASHI Shun (Univ. Tokyo, Tokyo, JPN) ,  SAWATSUBASHI Shun (JST-ERATO, Saitama, JPN) ,  MURATA Takuya (Univ. Tokyo, Tokyo, JPN) ,  FURUTANI Takashi (Astellas Pharma Inc., Ibaraki, JPN) ,  SHIRODE Yuko (Univ. Tokyo, Tokyo, JPN) ,  SHIRODE Yuko (JST-ERATO, Saitama, JPN) ,  YAMAGATA Kaoru (Univ. Tokyo, Tokyo, JPN) ,  YAMAGATA Kaoru (JST-ERATO, Saitama, JPN) ,  TANABE Masahiko (Univ. Tokyo, Tokyo, JPN) ,  KIMURA Shuhei (Univ. Tokyo, Tokyo, JPN) ,  UEDA Takashi (Univ. Tokyo, Tokyo, JPN) ,  FUJIYAMA Sally (Univ. Tokyo, Tokyo, JPN) ,  FUJIYAMA Sally (JST-ERATO, Saitama, JPN) ,  LIM Jinseon (Univ. Tokyo, Tokyo, JPN) ,  MATSUKAWA Hiroyuki (Univ. Tokyo, Tokyo, JPN) ,  KOUZMENKO Alexander P. (Univ. Tokyo, Tokyo, JPN) ,  KOUZMENKO Alexander P. (JST-ERATO, Saitama, JPN) ,  AIGAKI Toshiro (Tokyo Metropolitan Univ., Tokyo, JPN) ,  TABATA Tetsuya (Univ. Tokyo, Tokyo, JPN) ,  TAKEYAMA Ken-ichi (Univ. Tokyo, Tokyo, JPN) ,  KATO Shigeaki (Univ. Tokyo, Tokyo, JPN) ,  KATO Shigeaki (JST-ERATO, Saitama, JPN)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 106  Issue： 10  Page： 3818-3822  Publication year： Mar. 10, 2009 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： neurotoxicity ,  androgen receptor ,  polyamino acid ,  mutant ,  repetitive sequence ,  male sex hormone ,  nervous system disease ,  screening (inspection) ,  protective action ,  *Rb protein ,  acetyltransferase ,  histone deacetylase ,  transcription factor ,  *movement disorder ,  *Muscular Atrophy ,  gene expression ,  intermolecular interaction ,  nucleotide sequence ,  CAG repeat ,  Histone Acetyltransferases ,  polyglutamine ,  Drosophila ,  Histone Deacetylase 1 ,  protein-protein interaction ,  molecular genetic phenomenon ,  Diptera ,  invertebrate
Semi thesaurus term： Drosophila ,  E2F ,  HDAC1 ,  SBMA ,  Nerve Degeneration ,  *Muscular Atrophy, Spinal ,  *retinoblastoma protein ,  protein interaction

JST classification (2)： Biological function  (EB03040U) ,  Basic neurology  (GN01020W)

Terms in the title (6)： 神経毒性 ,  アンドロゲン受容体 ,  ポリグルタミン ,  伸張 ,  E2F ,  活性化