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J-GLOBAL ID：200902271275822391   Reference number：03A0232404

Changes of p27^Kip1 in rat tongue carcinoma cells induced by 4-nitroquinoline 1-oxide.

4-nitroquinoline 1-oxide誘発ラット舌癌細胞におけるp27^Kip1の分解

Author (2)： AOYAGI NOBUYOSHI (大阪歯科大 大学院歯学研究科 口腔外科学専攻) ,  UENO SHIGERU (大阪歯科大 口腔外科学第一)
Material： 歯科医学  (Journal of the Osaka Odontological Society)
Volume： 66  Issue： 1  Page： 32-38  Publication year： Mar. 25, 2003 
JST Material Number： G0582A  ISSN： 0030-6150  CODEN： SIGAA  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： rat ,...
Semi thesaurus term： p27

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JST classification (2)： Basic dentistry(= odontology)  (GT01020O) ,  Carcinogenic mechanisms and factors  (GE02020C)

Substance index (1)： 4-Nitroquinoline-1-oxide

Reference (17)：

• 1) KAWAMATA N. Molecular analysis of the cyclin-dependent kinase inhibitor gene p 27/Kip 1 in human malignancies. Cancer Res. (1995) vol.55, p.2266-2269.
• 2) KUDO Y. Reduced expression of cyclin-dependent kinase inhibitor p27Kip 1 is an indicator of malignant behavior in oral squamous cell carcinoma. Cancer. (1998) vol.83, p.2447-2455.
• 3) PONCE-CASTANEDA MV. p27^<Kip1> : chromosomal mapping to 12p 12-12p 13.1 and absence of mutations in human tumors. Cancer Res. (1995) vol.55, p.1211-1214.
• 4) LODA M. Increased proteasomedependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med. (1997) vol.3, p.231-234.
• 5) POLYAK K. Cloning of p27 Kip 1, a cyclin-dependent kinase inhibitory and potential mediator of extracellular antimitogeic signals. Cell. (1994) vol.78, p.59-66.

Terms in the title (6)： 誘発 ,  ラット ,  舌癌 ,  細胞 ,  p27Kip1 ,  分解