Art

J-GLOBAL ID：200902271456307073   Reference number：07A0232079

Characterization of CS-023 (RO4908463), a Novel Parenteral Carbapenem Antibiotic, and Meropenem as Substrates of Human Renal Transporters

ヒト腎臓輸送体の基質として新奇な非経口カルバペネム系抗生物質,CS-023(RO4908463),及びメロペネムの特性

Author (6)： SHIBAYAMA TAKAHIRO (Sankyo Co., Ltd., Tokyo, JPN) ,  SUGIYAMA DAISUKE (Sankyo Co., Ltd., Tokyo, JPN) ,  KAMIYAMA EMI (Sankyo Co., Ltd., Tokyo, JPN) ,  TOKUI TARO (Sankyo Co., Ltd., Tokyo, JPN) ,  HIROTA TAKASHI (Sankyo Co., Ltd., Tokyo, JPN) ,  IKEDA TOSHIHIKO (Sankyo Co., Ltd., Tokyo, JPN)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 22  Issue： 1  Page： 41-47  Publication year： Feb. 25, 2007 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *carbapenem antibiotics ,...
Semi thesaurus term： inhibition constant ,...

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JST classification (3)： Basic biopharmacy  (GY01021U) ,  Transport of cell membrane  (EF04020R) ,  Pharmacology of antibiotics in general  (GX05010R)

Substance index (5)： CS-023 ,  p-Aminohippuric Acid ,  Probenecid ,  Meropenem ,  Penicillin G

Reference (32)：

• KAWAMOTO, I. Synthesis and structure-activity relationships of novel parenteral carbapenems, CS-023 (R-115685) and related compounds containing an amidine moiety. J. Antibiot. 2003, 56, 565-579
• THOMSON, K. S. CS-023 (R-115685), a novel carbapenem with enhanced in vitro activity against oxacillin-resistant staphylococci and Pseudomonas aeruginosa. J. Antimicrob. Chemother. 2004, 54, 557-562
• KOGA, T. In vitro and in vivo antibacterial activities of CS-023 (RO4908463), a novel parenteral carbapenem. Antimicrob. Agents Chemother. 2005, 49, 3239-3250
• CRAIG, W. A. The pharmacology of meropenem, a new carbapenem antibiotic. Clin. Infect. Dis. 1997, 24, Suppl 2, S266-S275
• CRAIG, W. A. Pharmacokinetic/pharmacodynamic parameters : rationale for antibacterial dosing of mice and men. Clin. Infect. Dis. 1998, 26, 1-10

Terms in the title (7)： ヒト ,  腎臓 ,  輸送体 ,  基質 ,  カルバペネム系抗生物質 ,  CS-023 ,  メロペネム