Art

J-GLOBAL ID：200902273493149553   Reference number：03A0412478

Enhanced Enzyme Activity and Enantioselectivity of Lipases in Organic Solvents by Crown Ethers and Cyclodextrins

クラウンエーテルおよびシクロデキストリンによる有機溶媒中のリパーゼの活性およびエナンチオ選択性の促進

Author (6)： MINE Y (Yamaguchi Univ., Ube, JPN) ,  FUKUNAGA K (Yamaguchi Univ., Ube, JPN) ,  ITOH K (Yamaguchi Univ., Ube, JPN) ,  YOSHIMOTO M (Yamaguchi Univ., Ube, JPN) ,  NAKAO K (Yamaguchi Univ., Ube, JPN) ,  SUGIMURA Y (Oshima National Coll. Maritime Technol., Yamaguchi, JPN)
Material： Journal of Bioscience and Bioengineering  (J Biosci Bioeng)
Volume： 95  Issue： 5  Page： 441-447  Publication year： May. 25, 2003 
JST Material Number： G0535B  ISSN： 1389-1723  CODEN： JBBIF6  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： crown ether ,...
Semi thesaurus term： Candida

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JST classification (1)： Applications of enzymes  (EB09100B)

Substance index (3)： Diisopropyl ether ,  Butyric acid vinyl ,  2,2-Dimethyl-1,3-dioxolane-4-methanol

Reference (35)：

• 1. Dabulis, K. and Klibanov, A. M.: Dramatic enhancement of enzymatic activity in organic solvents by lyoprotectants. Biotechnol. Bioeng., 41, 566–571 (1993).
• 2. Mine, Y., Fukunaga, K., Yoshimoto, M., Nakao, K., and Sugimura, Y.: Modification of lipases with poly(ethylene glycol) and poly(oxyethylene) detergents and their catalytic activities in organic solvents. J. Biosci. Bioeng., 92, 539–543 (2001).
• 3. Reinhoudt, D. N., Eendebak, A. M., Nijenhuis, W. F., Verboom, W., Kloosterman, M., and Schoemaker, H. E.: The effect of crown ethers on enzyme-catalyzed reactions in organic solvents. J. Chem. Soc. Chem. Commun., 399–400 (1989).
• 4. Itoh, T., Hiyama, Y., Betchaku, A., and Tsukube, H.: Enhanced reaction rate and enantioselectivity in lipase-catalyzed hydrolysis by addition of a crown ether. Tetrahedron Lett., 34, 2617–2620 (1993).
• 5. Itoh, T., Takagi, Y., Murakami, T., Hiyama, Y., and Tsukube, H.: Crown ethers as regulators of enzymatic reactions: enhanced reaction rate and enantioselectivity in lipase-catalyzed hydrolysis of 2-cyano-1-methylethyl acetate. J. Org. Chem., 61, 2158–2163 (1996).

Terms in the title (7)： クラウンエーテル ,  シクロデキストリン ,  有機溶媒 ,  リパーゼ ,  活性 ,  エナンチオ選択性 ,  促進