Art

J-GLOBAL ID：200902274631339128   Reference number：09A1250115

Trientine, a Copper-Chelating Agent, Induced Apoptosis in Murine Fibrosarcoma Cells by Activation of the p38 MAPK Pathway

トリエンチン,銅キレート剤はp38 MAPK経路の活性化によりマウス線維肉腫細胞のアポトーシスを誘発した

Author (4)： KADOWAKI Shingo (Rakuno Gakuen Univ., Hokkaido, JPN) ,  ENDOH Daiji (Rakuno Gakuen Univ., Hokkaido, JPN) ,  OKUI Toyo (Rakuno Gakuen Univ., Hokkaido, JPN) ,  HAYASHI Masanobu (Rakuno Gakuen Univ., Hokkaido, JPN)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 71  Issue： 11  Page： 1541-1544  Publication year： Nov. 25, 2009 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *Copper ,...
Semi thesaurus term： p38 MAPK

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JST classification (2)： Cell physiology in general  (EF02010S) ,  Aliphatic amines,imines,quaternary ammonium,immonium compounds  (CF03070L)

Substance index (2)： Trientine ,  SB-203580

Reference (30)：

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• 2. Ballif, B. A. and Blenis, J. 2001. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 12: 397-408.
• 3. Bicknell, R. and Harris, A. L. 1996. Mechanisms and therapeutic implications of angiogenesis. Curr. Opin. Oncol. 8: 60-65.
• 4. Brem, S., Grossman, S. A., Carson, K. A., New, P., Phuphanich, S., Alavi, J. B. and Mikkelsen, T. 2005. Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma. Neuro-oncology 7: 246-253.
• 5. Brem, S., Zagzag, D., Tsanaclis, A. M. C., Gatley, S., Elkouby, M. P. and Brien, S. E. 1990. Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor. Am. J. Pathol. 137: 1121-1142.

Terms in the title (10)： トリエンチン ,  銅キレート剤 ,  P38 ,  MAPK経路 ,  活性化 ,  マウス ,  線維肉腫 ,  細胞 ,  アポトーシス ,  誘発