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J-GLOBAL ID:200902274632310549   Reference number:09A0235581

Telmisartan Decreases Plasma Levels of Asymmetrical Dimethyl-L-Arginine and Improves Lipid and Glucose Metabolism and Vascular Function

テルミサルタンは非対称ジメチル-L-アルギニンの血漿中濃度を低下させ脂質ならびに糖代謝と血管機能を改善する
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Volume: 50  Issue:Page: 73-83 (J-STAGE)  Publication year: 2009 
JST Material Number: Z0752A  ISSN: 1349-2365  Document type: Article
Article type: 原著論文  Country of issue: Japan (JPN)  Language: ENGLISH (EN)
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Drug therapy(=pharmacotherapy)for cardiovascular system diseases 
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Reference (35):
  • 1. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Münzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001; 104: 2673-8.
  • 2. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
  • 3. Cooke JP, Dzau VJ. Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. Circulation 1997; 96: 379-82. (Review)
  • 4. Vallance P, Leone A, Calver A, Collier J, Moncada S. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol 1992; 20: S60-2.
  • 5. Delles C, Schneider MP, John S, Gekle M, Schmieder RE. Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N (G), N (G) -dimethylarginine in human essential hypertension. Am J Hypertens 2002; 15: 590-3.
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