Art

J-GLOBAL ID：200902275627853727   Reference number：09A0241427

Diastereo- and Enantioselective Synthesis of β-Hydroxy-α-Amino Acids: Application to the Synthesis of a Key Intermediate for Lactacystin

β-ヒドロキシ-α-アミノ酸のジアステレオ-及びエナンチオ選択的合成 ラクタシスチンの重要中間体の合成への適用

Author (5)： LI Qiong (Lanzhou Univ., Lanzhou, CHN) ,  YANG Shao-Bo (Lanzhou Univ., Lanzhou, CHN) ,  ZHANG Zhihui (Lanzhou Univ., Lanzhou, CHN) ,  LI Lei (Lanzhou Univ., Lanzhou, CHN) ,  XU Peng-Fei (Lanzhou Univ., Lanzhou, CHN)
Material： Journal of Organic Chemistry  (J Org Chem)
Volume： 74  Issue： 4  Page： 1627-1631  Publication year： Feb. 20, 2009 
JST Material Number： C0328A  ISSN： 0022-3263  CODEN： JOCEAH  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *amino acid ,  *hydroxy acid ,  *asymmetric synthesis ,  aldehyde ,  template reaction ,  enolate ,  imine ,  lactone ,  aldol reaction ,  Hydrolysis ,  synthetic intermediate ,  bridged compound ,  Lithium Chloride ,  additive effect ,  alicyclic ketone ,  bicyclic monoterpene ,  aliphatic aldehyde ,  aromatic aldehyde ,  Oxazines ,  antiphlogistic
Semi thesaurus term： oxazine ,  イミノラクトン ,  bridged compound

JST classification (5)： Amino acids  (CF10070V) ,  Oxazines  (CF07100X) ,  Aliphatic aldehydes  (CF03180F) ,  Addition reaction,elimination reaction  (CF02030M) ,  Monoterpenes,sesquiterpenes  (CF10022A)

Substance index (18)： Camphor ,  Lactacystin ,  Acetaldehyde ,  Benzaldehyde ,  (1β)-8α,11,11-Trimethyl-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1β)-8α,11,11-Trimethyl-6-oxa-3-azatricyclo[6.2.1.0^2,7]undecane-2-ene-5-one ,  (1S,5S,8R)-5-[(S)-1-Hydroxyethyl]-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1S,5S,8R)-5-[(αR)-α-Hydroxybenzyl]-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1S,5S,8R)-5-[(αR)-α-Hydroxy-2-fluorobenzyl]-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1S,5S,8R)-5-[(αR)-α-Hydroxy-2-methoxybenzyl]-8,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1R,5R,8S)-1,11,11-Trimethyl-5-[(R)-1-hydroxyethyl]-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1R,5R,8S)-1,11,11-Trimethyl-5-[(αS)-α-hydroxybenzyl]-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1R,5R,8S)-1,11,11-Trimethyl-5-[(αS)-α-hydroxy-4-methoxybenzyl]-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (1R,5R,8S)-1,11,11-Trimethyl-5-[(1R)-1-hydroxyheptyl]-3-oxa-6-azatricyclo[6.2.1.0^2,7]undecane-6-ene-4-one ,  (2S)-2-Amino-3-hydroxybutyric acid ,  (2S)-2-Amino-3-hydroxynonanoic acid ,  (3R)-exo-3-Hydroxycamphor ,  (2S)-exo-2-Hydroxyepicamphor

Terms in the title (4)： α-アミノ酸 ,  エナンチオ選択的合成 ,  ラクタシスチン ,  中間体