Art

J-GLOBAL ID：200902275693981671   Reference number：03A0752165

Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hind-limb function after thoracic spinal cord injury in rat

p38マイトージェン活性化蛋白質キナーゼの選択的抑制剤であるSB203580の持続的髄膜内注入がラットの胸髄損傷後の後肢機能障害を減少させる

Author (5)： HORIUCHI H (Ehime Univ., Ehime, JPN) ,  OGATA T (Ehime Univ., Ehime, JPN) ,  MORINO T (Ehime Univ., Ehime, JPN) ,  CHUAI M (Ehime Univ., Ehime, JPN) ,  YAMAMOTO H (Ehime Univ., Ehime, JPN)
Material： Neuroscience Research  (神経科学)
Volume： 47  Issue： 2  Page： 209-217  Publication year： Oct. 2003 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *MAP kinase ,...

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JST classification (2)： Central nervous system  (EJ12030F) ,  Basic neurology  (GN01020W)

Substance index (1)： SB-203580

Reference (38)：

• ATZORI, C. Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. J. Neuropathol. Exp. Neurol. 2001, 60, 1190-1197
• BARONE, F. C. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J. Pharmacol. Exp. Ther. 2001, 296, 312-321
• BARONE, F. C. Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ishemia. Med. Res. Rev. 2001, 21, 129-145
• BASSO, D. M. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 1996, 139, 244-256
• BENVENISTE, H. Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 1984, 43, 1369-1374

Terms in the title (11)： P38 ,  活性化 ,  蛋白質キナーゼ ,  抑制剤 ,  SB203580 ,  髄膜 ,  注入 ,  ラット ,  胸髄損傷 ,  後肢 ,  機能障害