Art

J-GLOBAL ID：200902276083856863   Reference number：08A0146364

Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation

Dok1はPPAR-γのリン酸化修飾を介して高脂肪食が誘導する脂肪細胞の肥大化と肥満を仲介する

Author (16)： HOSOOKA Tetsuya (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  NOGUCHI Tetsuya (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  KOTANI Ko (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  NAKAMURA Takehiro (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  SAKAUE Hiroshi (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  INOUE Hiroshi (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  OGAWA Wataru (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  TOBIMATSU Kazutoshi (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  TAKAZAWA Kazuo (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  SAKAI Mashito (Kobe Univ. Graduate School of Medicine, Kobe, JPN) ,  MATSUKI Yasushi (DainipponSumitomo Pharma, Takarazuka, JPN) ,  HIRAMATSU Ryuji (DainipponSumitomo Pharma, Takarazuka, JPN) ,  YASUDA Tomoharu (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  LAZAR Mitchell A (Univ. Pennsylvania School of Medicine, Pennsylvania, USA) ,  YAMANASHI Yuji (Tokyo Medical and Dental Univ., Tokyo, JPN) ,  KASUGA Masato (Kobe Univ. Graduate School of Medicine, Kobe, JPN)
Material： Nature Medicine  (Nat Med)
Volume： 14  Issue： 2  Page： 188-193  Publication year： Feb. 01, 2008 
JST Material Number： W0636A  ISSN： 1078-8956  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *tyrosine kinase ,...
Semi thesaurus term： *Dok1 ,...

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JST classification (1)： Metabolic diseases,nutritional diseases in general.  (GD05010J)

Terms in the title (9)： PPAR-γ ,  リン酸化 ,  修飾 ,  高脂肪食 ,  誘導 ,  脂肪細胞 ,  肥大 ,  肥満 ,  仲介