Art

J-GLOBAL ID：200902276194176314   Reference number：08A1251373

Bioreductive activation of quinone antitumor drugs by mitochondrial voltage-dependent anion channel 1

ミトコンドリアの電圧依存的アニオンチャンネル1によるキノン抗癌剤の生体内還元性活性化

Author (7)： SIMAMURA Eriko (Kanazawa Medical Univ.) ,  SHIMADA Hiroki (Kanazawa Medical Univ.) ,  ISHIGAKI Yasuhito (Kanazawa Medical Univ.) ,  ISHIGAKI Yasuhito (Kanazawa Medical Univ., Ishikawa, JPN) ,  HATTA Toshihisa (Kanazawa Medical Univ.) ,  HIGASHI Nobuaki (Kanazawa Medical Univ.) ,  HIRAI Kei-Ichi (Kanazawa Medical Univ.)
Material： Anatomical Science International  (Anat Sci Int)
Volume： 83  Issue： 4  Page： 261-266  Publication year： Dec. 2008 
JST Material Number： W1346A  ISSN： 1447-6959  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： quinone ,...
Semi thesaurus term： *VDAC1 ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=08A1251373&from=J-GLOBAL&jstjournalNo=W1346A") }}

JST classification (2)： Biological function  (EB03040U) ,  Transport of cell membrane  (EF04020R)

Substance index (3)： 2-Methylnaphtho(2,3-b)furan-4,9-dione ,  NADH ,  Menadione

Reference (36)：

• BACHUR, NR. NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci USA. 1979, 76, 954-957
• BAKER, MA. VDAC1 is a transplasma membrane NADH-ferricyanide reductase. J Biol Chem. 2004, 279, 4811-4819
• COLOMBINI, M. Structure and mode of action of a voltage dependent anion-selective channel (VDAC) located in the outer mitochondrial membrane. Ann N Y Acad Sci. 1980, 341, 552-563
• CROMPTON, M. Mitochondrial intermembrane junctional complexes and their involvement in cell death. Biochimie. 2002, 84, 143-152
• DESMOND, JC. The synthetic furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cells. Br J Haematol. 2005, 131, 520-529

Terms in the title (6)： ミトコンドリア ,  アニオンチャンネル ,  キノン ,  抗癌剤 ,  生体内還元 ,  活性化